Blood transfusion safety in the country of Georgia: collateral benefit from a national hepatitis C elimination program.

Background: In April 2015, the government of Georgia (country) initiated the world's first national hepatitis C elimination program. An analysis of blood donor infectious screening data was conducted to inform a strategic plan to advance blood transfusion safety in Georgia.

Study Design And Methods: Descriptive analysis of blood donation records (2015-2017) was performed to elucidate differences in demographics, donor type, remuneration status, and seroprevalence for infectious markers (hepatitis C virus antibody [anti-HCV], human immunodeficiency virus [HIV], hepatitis B virus surface antigen [HBsAg], and Treponema pallidum).

HEPATITIS B VACCINATION: KNOWLEDGE AND ATTITUDE AMONG WOMEN OF REPRODUCTIVE AGE IN GEORGIA.

Georgia is a country with high prevalence of hepatitis B. Based on a 2015 population serosurvey, the prevalence of hepatitis B surface antigen (HBsAg) is 2.9% and prevalence of anti-HBc is 25.

CHARACTERISTICS OF GAMMA OSCILLATIONS INDUCED BY KAINATE PRESSURE EJECTION ON CA1 HIPPOCAMPUS OF MICE BRAIN SLICES IN SUBMERGED CHAMBERS.

Aim - mostly, gamma oscillations are studied in interface-type chambers. The purpose of the presented investigation is to describe the characteristics of gamma oscillations induced in submerged chambers by kainite pressure ejection. Horizontal combined entorhynal-hippocampal slices 300-350 µm were prepared from young mice (P18-28).

Timing of action potentials and input currents in perisomatic and trilaminar interneurons during kainate induced gamma oscillations in mice CA1 hippocampus.

Nonaccommodating perisomatic basket cells had been suggested to structure gamma oscillations. Here we used simultaneous whole-cell patch clamp recordings within 150 microm of CA1 stratum pyramidale and extracellular population activity measurements in CA1 stratum radiatum of the mice hippocampal slices to show that though nonaccommodating perisomatic interneurons and trilaminar cells convey information through the same frequency of action potentials during the kainate micropressure ejection induced gamma oscillations, inhibitory inputs received by soma and proximal dendrites of pyramidal cells differ with pi radian in time. Perisomatic interneurons discharge action potentials (APs) at the positive peak of the field gamma waves, whereas trilaminar cells fire at the trough.

[Morphological changes in brain and heart after the temporary liver exclusion from the bloodstream during the cholestasis].

The aim of the study was the detection of the peculiarities of the changes in brain and heart, developed by the cholestasis after ischemia (due to the temporary liver exclusion from the bloodstream) and post-ischemic restoration of bloodstream. The experimental study was carried out on 12 mature rats (weight 150-200 g). After the creation of 5 day cholestasis pattern, the exploration and clamping of the hepato-duodenal ligament was done for 10 minutes.