Effect of nirmatrelvir/ritonavir (Paxlovid) on hospitalization among adults with COVID-19: An electronic health record-based target trial emulation from N3C.

Background: Nirmatrelvir with ritonavir (Paxlovid) is indicated for patients with Coronavirus Disease 2019 (COVID-19) who are at risk for progression to severe disease due to the presence of one or more risk factors. Millions of treatment courses have been prescribed in the United States alone. Paxlovid was highly effective at preventing hospitalization and death in clinical trials.

Variations and Opportunities in Postnatal Management of Hemolytic Disease of the Fetus and Newborn.

Importance: Preventive efforts in pregnancy-related alloimmunization have considerably decreased the prevalence of hemolytic disease of the fetus and newborn (HDFN). International studies are therefore essential to obtain a deeper understanding of the postnatal management and outcomes of HDFN. Taken together with numerous treatment options, large practice variations among centers may exist.

Priorities of the Pediatric Spinal Cord Injury Population: An International Study on Patient-Reported Outcome Measures.

Background/objectives: Overall priorities of the international pediatric-onset spinal cord injury (SCI) population are unknown. The purpose was to describe and compare Life and Health (L&H) domain overall priorities of European youth with SCI and their parents and caregivers (P&C).

Methods: A survey with a cross-sectional design, prepared by the PEPSCI Collaboration, was conducted in six European countries.

Perforation of sigmoid colon by a migrated intrauterine contraceptive device (IUCD), diagnosis and surgical management: a case report.

We describe the case of a 43-year-old woman presented with an 8-month history of intermittent non-specific abdominal pain. She had an Intrauterine Contraceptive Device (IUCD) inserted 4-years ago and the device was still in-situ. After initial gynaecological assessment, further clinical radiological investigations, computerized tomography imaging showed that the intraluminal part of the radiological foreign body was seen to be possibly perforating the sigmoid colon after having migrated.