Publications by authors named "E G Isaeva"
Recent work demonstrates that epidermal keratinocytes are critical for normal touch sensation. However, it is unknown whether keratinocytes contribute to touch-evoked pain and hypersensitivity after tissue injury. Here, we used a mouse model of paclitaxel treatment to determine the extent to which keratinocyte activity contributes to the severe neuropathic pain that accompanies chemotherapy.
View Article and Find Full Text PDFIn this study, the optimal engraving parameters were determined through the analysis of scanning electron microscopy (SEM) data, as follows: a laser power density of 5.5 × 10 W/cm, an irradiation rate of 0.1 mm/s, a well radius of 60 μm, a distance between well centers of 200 μm, and a number of passes for each well of 20.
View Article and Find Full Text PDFArticle Synopsis
- Acromegaly, a condition caused by excessive growth hormone and IGF-1, negatively affects patients' quality of life and is conventionally treated with healthcare-administered therapies, while CAM2029 offers a self-administered option with better convenience and storage.
- A 24-week phase 3 trial involving 72 patients assessed the effectiveness of CAM2029 compared to placebo, focusing on the control of IGF-1 levels and GH.
- Results at Week 22/24 showed that CAM2029 significantly outperformed placebo in controlling IGF-1 and GH levels, leading to improved symptoms, quality of life, and patient satisfaction.
Inhibition of mTORC2 promotes natriuresis in Dahl salt-sensitive rats via the decrease of NCC and ENaC activity.
Am J Physiol Renal Physiol
September 2024
Article Synopsis
- This study compares the effects of two mTOR inhibitors, rapamycin and PP242, on hypertension and kidney function in salt-sensitive rats.
- While rapamycin reduced hypertension and kidney inflammation, only PP242 completely prevented hypertension and improved kidney health, showing significant natriuretic effects.
- The research identified that PP242's natriuretic effect primarily results from inhibiting the Na-Cl cotransporter and reducing Na channel activity, suggesting it may be a better therapeutic option for managing blood pressure and kidney injury in salt-sensitive individuals.