"A Friend Among Strangers" or the Ambiguous Roles of Runx2.

The transcription factor Runx2 plays a crucial role in regulating osteogenic differentiation and skeletal development. This factor not only controls the expression of genes involved in bone formation, but also interacts with signaling pathways such as the Notch pathway, which are essential for body development. However, studies have produced conflicting results regarding the relationship between Runx2 and the Notch pathway.

[The association of polymorphisms of the serotonin transporter gene SLC6A4 with depression].

Objective: To study the relationship of polymorphic variants of the SLC6A4 gene with depression among people aged 25-44 years in Novosibirsk.

Material And Methods: Under the WHO program «MONICA-psychosocial (MOPSY)», a random representative sample of people aged 25-44 years from the population of the Oktyabrsky district of Novosibirsk (men =725, mean age 43.4±0.

Prediction of biomass accumulation and tolerance of wheat seedlings to drought and elevated temperatures using hyperspectral imaging.

Early prediction of important agricultural traits in wheat opens up broad prospects for the development of approaches to accelerate the selection of genotypes for further breeding trials. This study is devoted to the search for predictors of biomass accumulation and tolerance of wheat to abiotic stressors. Hyperspectral (HS) and chlorophyll fluorescence (ChlF) parameters were analyzed as predictors under laboratory conditions.

Crosstalk between G-Quadruplexes and Dnmt3a-Mediated Methylation of the Oncogene Promoter.

The methylation of cytosines at CpG sites in DNA, carried out de novo by DNA methyltransferase Dnmt3a, is a basic epigenetic modification involved in gene regulation and genome stability. Aberrant CpG methylation in gene promoters leads to oncogenesis. In oncogene promoters, CpG sites often colocalize with guanine-rich sequences capable of folding into G-quadruplexes (G4s).

Association of the Gene Polymorphism with Depression in White Adults in the WHO "MONICA-Psychosocial" Program.

The gene polymorphism is associated with the risk of the development of several neurological disorders. The aim of the study was to investigate the association of the gene polymorphism with depression in the white adult population aged 25-64 years in Novosibirsk (Western Siberia). The third screening of the WHO program "MONICA-psychosocial" was conducted in 1994-1995.