Publications by authors named "E G Dronova"
Article Synopsis
- Ferritin-based hybrids are large macromolecules with potential uses in drug delivery and vaccines, but their design is complicated.
- Researchers designed hybrids using ferritin from Helicobacter pylori and a Small Ubiquitin-like Modifier, discovering that their assembly was influenced by varying preparation methods.
- They developed a quantitative model to analyze how different stoichiometries affected the structure of these hybrids, revealing unexpected patterns and establishing a framework for better design of ferritin-based systems.
Branched-chain amino acids (BCAAs) play an important role in the functioning of mammalian cells and the central nervous system. However, available genetically encoded indicators for BCAAs are based on Förster resonance energy transfer and have a limited dynamic range. We developed a single fluorescent protein-based sensor for BCAAs, called NeIle, which is composed of circularly permutated mNeonGreen protein inserted into the leucine-isoleucine-valine binding protein (LIVBP) from bacteria.
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- Actin exists in three forms: monomeric globular (G-actin), polymeric fibrillar (F-actin), and an inactivated form called I-actin, which forms without cellular folding machinery.
- The transformation from G-actin to I-actin can occur through various methods, including removal of divalent ions, mild denaturants, or heat, and I-actin can aggregate into oligomers of about 14-16 G-actin monomers.
- This study uses small-angle X-ray scattering to investigate the oligomerization process of I-actin, distinguishing it from F-actin and revealing a unique pathway of oligomer formation.
F-type ATP synthases play a key role in oxidative and photophosphorylation processes generating adenosine triphosphate (ATP) for most biochemical reactions in living organisms. In contrast to the mitochondrial FF-ATP synthases, those of chloroplasts are known to be mostly monomers with approx. 15% fraction of oligomers interacting presumably non-specifically in a thylakoid membrane.
View Article and Find Full Text PDFThe paper presents literature review and clinical case of patient with fibromyxoid sarcoma of maxilla illustrating diagnostic difficulties and efficacy of multidisciplinary treatment approach.
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