Insights into Early Interactions on Innovative Developments with European Regulators.

Introduction: The European Medicines Agency Innovation Task Force (ITF) acts as early point of contact for medicine and technology developers to enable innovation during early drug development stages through ITF briefing meetings.

Aim: To reflect on the current pace of innovation and to assess the potential of ITF stakeholder interactions, a comprehensive analysis of the ITF briefing meetings held between 2021 and 2022 was conducted with a focus on individual questions raised by the developers and the related feedback provided by the European regulators.

Methods: Questions raised during ITF briefing meetings were extracted and categorised into main and sub-categories, revealing different themes across the whole medicine development process such as manufacturing technologies, pre-clinical developments, and clinically relevant questions.

Few-cycle laser pulse characterization on-target using high-harmonic generation from nano-scale solids.

We demonstrate high-harmonic generation for the time-domain observation of the electric field (HHG-TOE) and use it to measure the waveform of ultrashort mid-infrared (MIR) laser pulses interacting with ZnO thin-films or WS monolayers. The working principle relies on perturbing HHG in solids with a weak replica of the pump pulse. We measure the duration of few-cycle pulses at 3200 nm, in reasonable agreement with the results of established pulse characterization techniques.

Sub-100 fs all-fiber polarization maintaining widely tunable laser at 2 µm.

An all-fiber polarization maintaining (PM) laser tunable over 170 nm via Raman soliton self-frequency shift (SSFS) delivering sub-100 fs pulses with a central wavelength ranging from 1880 to 2050 nm is presented. The 40 MHz laser emits power ranging from 15 to 34 mW with pulse duration as short as 80 fs. It is based on exclusively commercially available standard fibers and has been designed to produce sub-100 fs pulse durations over the whole spectral range without the need for adjusting neither nonlinearities nor dispersion.

Health-related behaviors and weight-related outcomes within sibling pairs: A systematic review.

Background: Siblings reciprocally contribute to mutual social and physical development. The aim of this review was to examine the health-related behaviors and weight-related outcomes within child-sibling pairs and to determine how these factors vary by sibling composition.

Methods: Following the PRISMA guidelines, a systematic review of studies published since 2000 obtained from MEDLINE, CINAHL, PubMed, Cochrane Reviews, Web of Science, PsycINFO, Health and Wellness, and Science Direct was performed.