Publications by authors named "E G Brockett"
Precise mechanisms are required to coordinate the locomotor activity of fore- and hind-limbs in quadrupeds and similar mechanisms persist to coordinate movement of arms and legs in humans. Propriospinal neurons (PSNs) are major components of the networks that coordinate these mechanisms. The b subunit of cholera toxin (CTb) was injected unilaterally into either L1 or L3 segments in order to label ascending and descending propriospinal pathways.
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- Rett syndrome is caused by mutations in the MECP2 gene, leading to various neurological issues in affected mice, such as motor function problems and abnormal breathing patterns.
- Research indicates that even after maturation, activating the Mecp2 gene in adult mice can reverse many of these symptoms and structural brain defects.
- The study suggests that while MECP2 is not critical for brain development, it is crucial for maintaining proper neurological functions in adults.