Effect of and Polymorphisms on COPD Predisposition and Lung Function in COPD Patients.

Certain transient receptor potential (TRP) channels including and are widely expressed in the respiratory tract and have been shown to be the receptors of cigarette smoke and particulate matter-the main causative factors of chronic obstructive pulmonary disease (COPD). The aim of the study was to investigate the effect of and polymorphisms on COPD predisposition and lung function in COPD patients. The study enrolled 143 COPD patients and 104 smokers with post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 70%.

[Functional characteristics of cardiovascular system in adolescents with prehypertension].

Based on the results of sanogenetic monitoring the health of schoolchildren found that among high school students to the proportion of adolescents with elevated blood pressure (hypertension + hypernormotension) increases from 15-20% in 8th class to 30-50% in 9-11th classes, while the proportion of adolescents with hypertension was 3.7% in all age groups. Comparison of blood pressure with parameters of neurovegetative regulation of the cardiovascular system revealed that the presence of high normal blood pressure in 13-14-year-olds and 17-18-year-olds correlated with an increase in the proportion of low frequencies in the spectrum of HRV and lower values of the sensitivity of arterial baroreflex.

[The level of cytokines in the ex vivo infection of murine macrophages with Mycobacterium tuberculosis complex].

To study whether the genotype of a mycobacterial strain might affect the ability of macrophages (MP) to produce the key cytokines, we determined the synthesis of interferon-gamma (IFN-gamma), tumor necrosis factor-gamma (TNF-gamma), and interleukin-6 (IL-6) in the infection of murine MP with M. tuberculosis H37Rv and M. bovis BCG, the strains that belong to the same genetic group (M.

[Mutation processes in the natural populations of Drosophila and Hirundo rustica from Ukrainian radiation contaminated territories].

Natural populations of Drosophila melanogaster and Hirundo rustica that reside at the territories with different levels of radioactive pollution were investigated. The levels of visible mutations, sex-linked mutations and gonad reduction of Drosophila and the rate of interphase markers of chromosomal instability in erythrocytes of birds were selected as parameters for population monitoring. The results point out to possible reverse dependence among the level of chromosomal instability of birds, the rate of lethal mutations in sex chromosome of Drosophila and the density of radioactive pollution.