Publications by authors named "E Fuller"
A complete understanding of RNA biology requires methods for tracking transcripts in vivo. Common strategies rely on fluorogenic probes that are limited in sensitivity, dynamic range, and depth of interrogation, owing to their need for excitation light and tissue autofluorescence. To overcome these challenges, we report a bioluminescent platform for serial imaging of RNAs.
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- Free-space all-optical diffractive neural networks are emerging technologies for recognizing and classifying scenes, and understanding their basic properties is crucial for their performance.
- Researchers investigated how the depth of these systems, achieved by adding more diffractive layers, influences classification accuracy while using a co-design modeling method.
- Although increasing depth improves accuracy while using fewer features compared to a single layer, it can't exceed the performance of an optimized single layer, as limitations arise from the fundamental physics of light, particularly the diminishing electric field strength with distance.
Any electrical signal propagating in a metallic conductor loses amplitude due to the natural resistance of the metal. Compensating for such losses presently requires repeatedly breaking the conductor and interposing amplifiers that consume and regenerate the signal. This century-old primitive severely constrains the design and performance of modern interconnect-dense chips.
View Article and Find Full Text PDFGreat apes have maintained a stable karyotype with few large-scale rearrangements; in contrast, gibbons have undergone a high rate of chromosomal rearrangements coincident with rapid centromere turnover. Here we characterize assembled centromeres in the Eastern hoolock gibbon, (HLE), finding a diverse group of transposable elements (TEs) that differ from the canonical alpha satellites found across centromeres of other apes. We find that HLE centromeres contain a CpG methylation centromere dip region, providing evidence this epigenetic feature is conserved in the absence of satellite arrays; nevertheless, we report a variety of atypical centromeric features, including protein-coding genes and mismatched replication timing.
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