Publications by authors named "E Fudim"
Aims And Background: Matrix metalloproteinase-7 (MMP-7) and Syndecan-1 (SDC1) are involved in multiple functions during tumorigenesis. We aimed to evaluate the diagnostic and prognostic performance of these serum proteins, as potential biomarkers, in patients with pancreatic ductal adenocarcinoma (PDAC) and benign pancreatic cysts.
Methods: In this case-control study, patients with newly diagnosed PDAC (N = 121) were compared with the benign cyst (N = 66) and healthy control (N = 48) groups.
Article Synopsis
- A study investigated the effectiveness of adalimumab, an anti-TNFα monoclonal antibody, in ulcerative colitis (UC) patients, revealing that fewer UC patients continued treatment compared to those with Crohn's disease (CD).
- In a cohort of 50 UC patients, only 22% maintained treatment through the follow-up period, while 51% of 98 CD patients did.
- The loss of response to treatment was notably higher in UC patients, with 34% developing antibodies against adalimumab, although immunogenicity rates were similar between both patient groups.
Article Synopsis
- - Ustekinumab is a monoclonal antibody used to treat Crohn's disease, with about 50% of patients achieving clinical remission after one year; the study aimed to find predictors of response to this treatment by analyzing blood samples before initiation.
- - RNA from blood samples of 36 adults with Crohn's was sequenced, identifying 22 responders and 14 nonresponders, but no significant gene expression signature was found between the two groups after correcting for false discovery rates.
- - Despite the lack of major differences in gene expression, nonresponders showed an increased inflammatory response with certain cytokine and chemokine receptor pathways, suggesting that further research with a larger sample is needed for validation.
Background And Aims: The expression of tissue and serum matrix metalloproteinase-7 (MMP-7) was shown to be elevated both in colon cancer and dysplastic lesions. We aimed to evaluate, for the first time, its role as a diagnostic marker in Lynch syndrome (LS) carriers, a hereditary syndrome with predisposition to colon cancer.
Methods: This was a case control study.
: Vedolizumab trough serum levels have been associated with clinical and endoscopic response in patients with inflammatory bowel disease (IBD). A recent study demonstrated that higher trough levels before dose escalation are associated with favorable outcomes. : We aimed to identify whether vedolizumab trough levels predict outcome of subsequent therapy.
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