Publications by authors named "E Frobert"
The H274Y substitution (N2 numbering) in neuraminidase (NA) N1 confers oseltamivir resistance to A(H1N1) influenza viruses. This resistance has been associated with reduced N1 expression using transfected cells, but the effect of this substitution on the enzymatic properties and on the expression of other group-1-NA subtypes is unknown. The aim of the present study was to evaluate the antiviral resistance, enzymatic properties, and expression of wild-type (WT) and H274Y-substituted NA for each group-1-NA.
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- - The study compared mortality rates and patient burden among adult ICU patients with respiratory failure due to RSV, COVID-19, seasonal influenza, and H1N1, involving a total of 807 patients.
- - Patients with RSV had more comorbidities, while those with COVID-19 presented with less severe conditions at admission, indicated by lower SAPS-II and SOFA scores.
- - Results showed that COVID-19 and H1N1 were linked to higher mortality rates compared to RSV, despite patients with RSV being more severely ill, suggesting a better overall outcome for those affected by RSV and seasonal influenza.
Pregnancy is a risk factor for acute respiratory failure (ARF) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We hypothesised that SARS-CoV-2 viral load in the respiratory tract might be higher in pregnant intensive care unit (ICU) patients with ARF than in non-pregnant ICU patients with ARF as a consequence of immunological adaptation during pregnancy. Single-centre, retrospective observational case-control study.
View Article and Find Full Text PDFData on herpes simplex virus (HSV) polymorphism as well as acyclovir (ACV) and foscarnet (FOS) resistance mutations are not exhaustive and may hinder accurate diagnosis by next-generation sequencing (NGS). Here, we report novel UL23 and UL30 substitutions for HSV1 and HSV2 identified in immunocompromised patients treated for hematological malignancies during the last 6 years of HSV resistance surveillance at the University Hospital of Lyon. For HSV1, 35 novel UL23 substitutions and 52 novel UL30 substitutions were identified.
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- Qualitative SARS-CoV-2 antigen tests are effective for mass COVID-19 diagnosis but are less sensitive than RT-PCR tests, while quantitative assays have the potential to enhance performance and examine various sample types.
- A study tested 26 patients and found N-antigen present in respiratory, plasma, and urine samples, with RNA only detected in respiratory and some plasma samples.
- The study concluded that urine N-antigen testing could aid in late-stage COVID-19 diagnosis and monitoring, due to its non-invasive nature and the prolonged presence of antigen in urine.