Publications by authors named "E Fritsche"
The workshop titled State of the Science on Assessing Developmental Neurotoxicity Using New Approach Methods was co-organized by University of Maryland's Joint Institute for Food Safety and Applied Nutrition (JIFSAN) and the U.S. Food and Drug Administration's (FDA) Center for Food Safety and Applied Nutrition (CFSAN; now called the Human Foods Program), and was hosted by FDA in College Park, MD on November 14-15, 2023.
View Article and Find Full Text PDFThe safety and developmental neurotoxicity (DNT) potential of chemicals remain critically understudied due to limitations of current in vivo testing guidelines, which are low throughput, resource-intensive, and hindered by species differences that limit their relevance to human health. To address these issues, robust New Approach Methodologies (NAMs) using deeply characterized cell models are essential. This study presents the comprehensive transcriptomic characterization of two advanced human-induced pluripotent stem cell (hiPSC)-derived models: a 2D adherent and a 3D neurosphere model of human neural progenitor cells (hiNPCs) differentiated up to 21 days.
View Article and Find Full Text PDFArticle Synopsis
- Cockayne Syndrome B (CSB) is a genetic disorder that can lead to brain issues such as small head size (microcephaly), learning difficulties (intellectual disability), and loss of protective nerve coverings (demyelination).
- Research using stem cell models from CSB patients reveals that these issues arise from problems like poor cell movement, altered brain signaling related to GABA, and immature support cells called oligodendrocytes.
- Treatments using HDAC inhibitors show promise in improving cell migration and oligodendrocyte development, which may help alleviate some symptoms of CSB.