Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition.

The permeability transition (PT) is a permeability increase of the mitochondrial inner membrane causing mitochondrial swelling in response to matrix Ca. The PT is mediated by regulated channel(s), the PT pore(s) (PTP), which can be generated by at least two components, adenine nucleotide translocator (ANT) and ATP synthase. Whether these provide independent permeation pathways remains to be established.

Relationship Between Extreme Rainfall Occurrences and Galactic Cosmic Rays over Natal/RN, Brazil: A Case Study.

The increase in Galactic Cosmic Rays (GCR) flux intensity induces the Condensation Nuclei (CN) production, which intensifies rainfall occurrences. Then, the objective of this study was to analyze the rainfall distribution in the NEB and the impact of GCR flux on extreme rainfall events occurred in July 1998 in Natal/RN, Brazil. We used historical rainfall, Sea Surface Temperature (SST) and GCR flux data for Natal/RN.

The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species.

The demonstration that FF (F)-ATP synthase and adenine nucleotide translocase (ANT) can form Ca-activated, high-conductance channels in the inner membrane of mitochondria from a variety of eukaryotes led to renewed interest in the permeability transition (PT), a permeability increase mediated by the PT pore (PTP). The PT is a Ca-dependent permeability increase in the inner mitochondrial membrane whose function and underlying molecular mechanisms have challenged scientists for the last 70 years. Although most of our knowledge about the PTP comes from studies in mammals, recent data obtained in other species highlighted substantial differences that could be perhaps attributed to specific features of F-ATP synthase and/or ANT.

Can Ki-67 predict radiotherapy response in neuroendocrine tumors? Retrospective analysis of a monocentric series of patients.

Background: The impact of radiotherapy (RT) in neuroendocrine neoplasms is still unknown, and outcomes could be improved by a better insight in RT response predictors. This retrospective analysis investigates the potential correlation between Ki-67 and RT response to evaluate its role as biological marker of radiosensitivity.

Material And Methods: Data from patients treated at an Italian NET-referral center between 2015 and 2020 were retrieved.