Publications by authors named "E Frare"
Article Synopsis
- - The study aimed to assess how common olfactory dysfunction is in patients using Isotretinoin (ISO) for acne treatment and what factors may influence this condition using the University of Pennsylvania Smell Identification Test (UPSIT®).
- - Involving 70 patients, results showed that 62.9% of ISO users experienced olfactory dysfunction compared to only 17.1% in non-users, with most cases being mild.
- - The findings indicated that olfactory issues were linked to longer treatment duration, higher cumulative doses of ISO, and nasal obstruction, even though most patients were unaware of their olfactory problems.
Crotamine is a rattlesnake-derived toxin that causes fast-twitch muscle paralysis. As a cell-penetrating polypeptide, crotamine has been investigated as an experimental anti-cancer and immunotherapeutic agent. We hypothesized that molecules targeting crotamine could be designed to study its function and intervene in its adverse activities.
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- Conditioned medium (CM) is a mixture of growth factors and cytokines secreted by cells that is crucial for cellular processes like growth and differentiation, and its composition varies by cell type.
- Osteoclasts, responsible for bone resorption, are influenced by growth factors produced by immune and cancer cells, which can either promote or inhibit their differentiation.
- In this study, CM from activated Jurkat-E6 cells had a stronger inhibitory effect on osteoclast formation compared to non-activated Jurkat-E6, B16-F10, and SK-MEL-28 cells, largely due to higher levels of IFN-γ in the activated CM.
Acquired aplastic anemia (AA) is a type of bone marrow failure (BMF) syndrome characterized by partial or total bone marrow (BM) destruction resulting in peripheral blood (PB) pancytopenia, which is the reduction in the number of red blood cells (RBC) and white blood cells (WBC), as well as platelets (PLT). The first-line treatment option of AA is given by hematopoietic stem cell (HSCs) transplant and/or immunosuppressive (IS) drug administration. Some patients did not respond to the treatment and remain pancytopenic following IS drugs.
View Article and Find Full Text PDFThe muscarinic effect of anhydroecgonine methyl ester, a crack cocaine pyrolysis product, impairs melatonin synthesis in the rat pineal gland.
Toxicol Res (Camb)
July 2017
Anhydroecgonine methyl ester (AEME), also called methylecgonidine, is a pyrolysis product of crack cocaine that is neurotoxic and potentiates cocaine-induced sensitization. The sensitization induced by drugs of abuse can be influenced by melatonin, a neuroprotective pineal hormone. In the same way, drugs of abuse like alcohol and methamphetamine can modify melatonin synthesis.
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