The suppressing effect of chlorpromazine treatment on alimentary-social differentiation in amygdala dogs.

Experiments were performed on dogs with bilateral electrolytic damage of dorso-medial amygdala. Before the operation dogs were trained in alimentary-social reward differentiation. It consisted in conditioning of instrumental responses of either right or left foreleg to two different tones respectively.

The alimentary and social instrumental performance in dogs is suppressed by various doses of amphetamine.

Amphetamine was administrated intramuscularly 20-25 min before each experimental session in doses of: 0.2 mg/kg, 0.5 mg/kg and 1.

Chlorpromazine exerts stronger suppressive action on the instrumental responses motivated by social than by alimentary reward.

Experiments were performed on six dogs over-trained before treatment, in differentiation of two instrumental responses, i.e. reinforced either by food or by sensory-social reward (petting by the experimenter).

Heart rate changes during consumption of preferred and non-preferred food under amphetamine treatment.

Heart rate was recorded in five dogs while they ate three kinds of foods varying in preference. Heart rate increased during the initial phase of eating, to the greatest extent with the most preferred food. dl-Amphetamine sulfate (0.