Publications by authors named "E Foffi"
Here, we investigated the potential interaction between bromodomain-containing protein 4 (BRD4), an established epigenetic modulator and transcriptional coactivator, and p63, a member of the p53 transcription factor family, essential for epithelial development and skin homeostasis. Our protein-protein interaction assays demonstrated a strong and conserved physical interaction between BRD4 and the p53 family members-p63, p73, and p53-suggesting a shared binding region among these proteins. While the role of BRD4 in cancer development through its interaction with p53 has been explored, the effects of BRD4 and Bromodomain and Extra Terminal (BET) inhibitors in non-transformed cells, such as keratinocytes, remain largely unknown.
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- The study investigates the role of p63, a transcription factor, in skin aging and keratinocyte senescence, revealing that the depletion of p63 accelerates aging markers in both animal models and human cells.
- Using advanced metabolomic analysis techniques, the research identifies key metabolic pathways linked to cell senescence that change when p63 is silenced, affecting stress markers and lipid production.
- Findings suggest that p63 plays a crucial role in managing metabolic processes in keratinocytes, potentially offering insights into therapeutic strategies against skin aging and related conditions.
MSC, mesenchymal stem cells; OPG, osteoprotegerin; RUNX2, Run-trelated transcription factor 2.
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