Publications by authors named "E Fodor"

Nipah virus is a highly virulent zoonotic paramyxovirus causing severe respiratory and neurological disease. Despite its lethality, there is no approved treatment for Nipah virus infection. The viral polymerase complex, composed of the polymerase (L) and phosphoprotein (P), replicates and transcribes the viral RNA genome.

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Plant-plant interactions are major determinants of the dynamics of terrestrial ecosystems. There is a long tradition in the study of these interactions, their mechanisms and their consequences using experimental, observational and theoretical approaches. Empirical studies overwhelmingly focus at the level of species pairs or small sets of species.

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Zoonotic influenza A virus (IAV) infections pose a substantial threat to global health. The influenza RNA-dependent RNA polymerase (RdRp) comprises the PB2, PB1, and PA proteins. Of the last four pandemic IAVs, three featured avian-origin PB1 genes.

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Article Synopsis
  • Hantaviridae is a family of RNA viruses that includes pathogens affecting humans and animals, and they contain a polymerase essential for their genome replication.
  • The study focuses on the expression and purification of the polymerase from the Hantaan virus, utilizing Cryo-EM to explore its structure in detail, achieving resolutions between 2.7 to 3.3 Å.
  • Important findings include the identification of new conformations of the polymerase and the observation of its interaction with RNA and nucleotides, which provide insights into its transcription and replication mechanism, paving the way for potential therapeutic developments.
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We develop a framework describing the dynamics and thermodynamics of open non-ideal reaction-diffusion systems, which embodies Flory-Huggins theories of mixtures and chemical reaction network theories. Our theory elucidates the mechanisms underpinning the emergence of self-organized dissipative structures in these systems. It evaluates the dissipation needed to sustain and control them, discriminating the contributions from each reaction and diffusion process with spatial resolution.

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