Lack of association of lobar intracerebral hemorrhage with apolipoprotein E genotype in an unselected population.

Background: Both the upsilon2 and upsilon4 alleles of the apolipoprotein E gene (APOE) have been reported to be overrepresented in lobar intracerebral hemorrhage and to be associated with cerebral amyloid angiopathy (CAA). These studies were performed primarily on the North American population and investigated in partly selected patient cohorts.

Methods: 193 consecutive patients suffering from primary intracerebral hemorrhage (ICH) were included in our study.

Frequency and location of microbleeds in patients with primary intracerebral hemorrhage.

Background And Purpose: MRI is known to detect clinically silent microbleeds (MBs) in patients with primary intracerebral hemorrhage (pICH), but the frequency and diagnostic and clinical significance of this finding are still debated. Therefore, we investigated a consecutive series of pICH patients and analyzed the patterns of MB distribution in the context of clinical variables and location of the symptomatic hematoma.

Methods: The study population consisted of 109 patients with pICH.

Apolipoprotein E genotype related differences in brain lesions of multiple sclerosis.

Objectives: Clinical reports have speculated on a more severe course of multiple sclerosis in patients with the apolipoprotein E (apoE) epsilon4 allele. As this could be reflected by differences in the severity of tissue damage MRI was used to obtain further support for a disease modifying effect of the apoE genotype.

Methods: Brain MR scans of 83 patients (mean age 35.

The spectrum of age-associated brain abnormalities: their measurement and histopathological correlates.

Magnetic resonance imaging (MRI) has dramatically increased our ability to detect morphological abnormalities in relation to aging of the brain. Among those changes are alterations of the white matter which display high signal intensity on both proton density and T2-weighted images. They may be seen in the deep and subcortical white matter or in a periventricular location.

[Attitude of patients with multiple sclerosis to illness information].

The timing and extent of information which should be given to sufferers from multiple sclerosis (MS) are usually discussed without knowing the patients' opinion. In a pilot study we therefore retrospectively asked 50 patients with relapsing MS (mean age 34 +/- 9 years) for their feelings before and after having been informed about suffering from this disease and in respect to the timing of this information by means of an anonymous questionnaire. The response rate was 86%.