Publications by authors named "E Fleck"
Article Synopsis
- Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition where a mother’s immune system attacks her fetus's platelets, primarily due to antibodies against the HPA-1a antigen; current prevention and treatment options are lacking.
- A study tested the efficacy of RLYB212, a monoclonal antibody that targets HPA-1a, to see if it could eliminate HPA-1a-positive platelets after a simulated fetal-maternal hemorrhage; subjects received either RLYB212 or a placebo in a blind trial.
- Results showed that RLYB212 significantly reduced HPA-1a-positive platelets and was well tolerated, indicating its promise as a potential
Virtual cardiovascular magnetic resonance training proves feasible and effective: survey data from international participants of the CMR Academy Berlin, Germany.
Eur Heart J Imaging Methods Pract
May 2023
Aims: This study aims to evaluate the success of the cardiovascular magnetic resonance (CMR) imaging Academy Berlin's transition from in-person to online CMR imaging training during the global pandemic 2020 and to gather recommendations for future courses.
Methods And Results: We conducted an online survey targeting CMR course participants from both the pre-pandemic, in-person era and the pandemic, online era of the CMR Academy Berlin. The survey primarily used Likert-type questions to assess participants' experiences and preferences.
Article Synopsis
- - Hypermobile Ehlers-Danlos syndrome (hEDS) is a common inherited connective tissue disorder, but its genetic causes are still unknown.
- - Researchers conducted whole exome sequencing on families and sporadic patients with hEDS, discovering a specific missense variant in the KLK15 gene linked to the disease.
- - By creating knock-in mice with this variant, they validated that it caused connective tissue defects, supporting the role of KLK15 gene variants in hEDS and promoting early diagnosis and improved clinical treatments.
Microfluidic artificial lungs (μALs) are a new class of membrane oxygenators. Compared to traditional hollow-fiber oxygenators, μALs closely mimic the alveolar microenvironment due to their size-scale and promise improved gas exchange efficiency, hemocompatibility, biomimetic blood flow networks, and physiologically relevant blood vessel pressures and shear stresses. Clinical translation of μALs has been stalled by restrictive microfabrication techniques that limit potential artificial lung geometries, overall device size, and throughput.
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