Publications by authors named "E Fibach"
Myelodysplastic syndrome (MDS) is a heterogeneous group of bone marrow stem cell disorders characterized by ineffective hematopoiesis and cytopenias, most commonly anemia. Red cell transfusion therapy for anemia in MDS results in iron overload, correlating with reduced overall survival. Whether the treatment of iron overload benefits MDS patients remains controversial.
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- The study evaluated the use of deferiprone (DFP), an oral iron-chelating drug, in patients with lower risk myelodysplastic syndromes (MDSs) who are dependent on red blood cell (RBC) transfusions and suffer from iron overload.
- Eighteen adult patients treated with DFP for 4 months showed significant reductions in oxidative stress markers, including a 58.6% decrease in reactive oxygen species (ROS), and improvements in other parameters like reduced glutathione and lipid peroxidation.
- No cases of agranulocytosis occurred during the study, indicating that DFP was tolerable, and the findings suggest potential benefits of D
Article Synopsis
- This study investigates the impact of free haem and iron on vascular health in patients with blood disorders like β-thalassaemia, hereditary spherocytosis, and sickle cell disease, showing that these substances can cause inflammation and vascular issues.
- Researchers found elevated levels of haem and iron in patients, leading to increased oxidative stress and markers of inflammation compared to healthy individuals.
- The findings suggest that targeting free haem and iron with specific therapies could help manage vascular dysfunction and inflammation in these blood disorders.
The Redox Balance and Membrane Shedding in RBC Production, Maturation, and Senescence.
Front Physiol
February 2021
Membrane shedding in the form of extracellular vesicles plays a key role in normal physiology and pathology. Partial disturbance of the membrane-cytoskeleton linkage and increased in the intracellular Ca content are considered to be mechanisms underlying the process, but it is questionable whether they constitute the primary initiating steps. Homeostasis of the redox system, which depends on the equilibrium between oxidants and antioxidants, is crucial for many cellular processes.
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