Publications by authors named "E Fernandez-varon"
Article Synopsis
- Multidrug-resistant (MDR) bacteria are a major global health issue, particularly in intensive care units (ICUs) where high antibiotic use contributes to resistance.
- This study evaluated the effects of a Selective Digestive Decontamination (SDD) protocol on antibiotic use and colonization by carbapenemase-producing Enterobacterale (CPE) in an ICU over two years.
- Results showed that implementing SDD significantly reduced overall antibiotic consumption (especially carbapenems) and colonization rates of CPE, indicating it could be an effective approach to combat antimicrobial resistance in critical care without promoting MDR bacteria.
Novel Genetic Variants Explaining Severe Adverse Drug Events after Clinical Implementation of Genotype-Guided Therapy with Fluoropyrimidines: An Observational Study.
Pharmaceutics
July 2024
Fluoropyrimidines (FPs) are commonly prescribed in many cancer streams. The EMA and FDA-approved drug labels for FPs recommend genotyping the *2A (rs3918290), *13 (rs55886062), *HapB3 (rs56038477), alleles, and rs67376798 before treatment starts. We implemented the genotyping in our daily clinical routine, but we still found patients showing severe adverse drug events (ADEs) to FPs.
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- Azathioprine is an immunosuppressive drug used for conditions like acute lymphoblastic leukemia and autoimmune disorders, with its effectiveness influenced by genetic factors such as TPMT and NUDT15 variants.
- The study investigated how adjusting azathioprine doses based on these genetic variations affects toxicity and efficacy in patients, specifically comparing those with intermediate and poor metabolizer genotypes against normal metabolizers.
- Findings indicated that patients with TPMT intermediate genotypes experienced fewer toxicity events and required fewer dose adjustments while maintaining similar treatment effectiveness as normal metabolizers, suggesting other genetic factors may also play a role in azathioprine's toxicity.
Population pharmacokinetics and pharmacokinetic/pharmacodynamic evaluation of marbofloxacin against Coagulase-negative staphylococci, Staphylococcus aureus and Mycoplasma agalactiae pathogens in goats.
Res Vet Sci
June 2023
Marbofloxacin is a broad-spectrum fluoroquinolone, and an extra-label use has been reported in horse, sheep and goat. However, extrapolation of dosage regimens from cattle to horse and small ruminants could lead to incorrect dosing due to pharmacokinetic differences among species, increasing the risk of antimicrobial resistance or toxicity. Pharmacokinetic properties of marbofloxacin, including PK/PD analysis, have been studied by intravenous, intramuscular and subcutaneous administration in lactating and non-lactating goats.
View Article and Find Full Text PDFThe SARS-CoV-2 infection has increased the number of patients entering Intensive Care Unit (ICU) facilities and antibiotic treatments. Concurrently, the multi-drug resistant bacteria (MDRB) colonization index has risen. Considering that most of these bacteria are derived from gut microbiota, the study of its composition is essential.
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