Publications by authors named "E Fedele"
Background: Great apes are a global conservation concern, with anthropogenic pressures threatening their survival. Genetic analysis can be used to assess the effects of reduced population sizes and the effectiveness of conservation measures. In humans, autosomal short tandem repeats (aSTRs) are widely used in population genetics and for forensic individual identification and kinship testing.
View Article and Find Full Text PDFSpinal cord injury (SCI) is a life-changing event that severely impacts the patient's quality of life. Modulating neuroinflammation, which exacerbates the primary injury, and stimulating neuro-regenerative repair mechanisms are key strategies to improve functional recovery. Cyclic adenosine monophosphate (cAMP) is a second messenger crucially involved in both processes.
View Article and Find Full Text PDFBackground: Sexual assault (SA) can lead to a range of adverse effects on physical, sexual, and mental health, as well as on one's social life, financial stability, and overall quality of life. However, not all people who experience SA will develop negative functional outcomes. Various risk and protective factors can influence psycho-socio-judicial trajectories.
View Article and Find Full Text PDFAnti-Amyloid Therapies for Alzheimer's Disease and the Amyloid Cascade Hypothesis.
Int J Mol Sci
September 2023
Article Synopsis
- Over the past 30 years, the main focus of Alzheimer's disease research has been on removing β-amyloid peptide (Aβ) from the brain based on the amyloid cascade hypothesis, which suggests that Aβ is a key cause of the disorder.
- However, recent clinical trials, including those for FDA-approved drugs Aducanumab, Lecanemab, and Donanemab, show that targeting Aβ has only had limited impact on improving cognitive function in patients.
- New evidence points out that Aβ may also have important roles in brain function, hinting that Alzheimer's could be caused by multiple factors, rather than just the presence of Aβ, suggesting a need for broader approaches in treatment.
Background: Electrocardiographic (ECG) findings in arrhythmogenic left ventricular cardiomyopathy (ALVC) are limited to small case series.
Objectives: This study aimed to analyze the ECG characteristics of ALVC patients and to correlate ECG with cardiac magnetic resonance and genotype data.
Methods: We reviewed data of 54 consecutive ALVC patients (32 men, age 39 ± 15 years) and compared them with 84 healthy controls with normal cardiac magnetic resonance.