Publications by authors named "E Falcinelli"
Genome-wide platelet transcriptomics is increasingly used to uncover new aspects of platelet biology and as a diagnostic and prognostic tool. Nevertheless, platelet isolation methods for transcriptomic studies are not standardized, introducing challenges for cross-study comparisons, data integration, and replication. In this prospective multicenter study, called "Standardizing Platelet Transcriptomics for Discovery, Diagnostics, and Therapeutics in the Thrombosis and Hemostasis Community (STRIDE)" by the International Society on Thrombosis and Haemostasis Scientific and Standardization Committees, we assessed how 3 of the most commonly used platelet isolation protocols influence metrics from next-generation bulk RNA sequencing and functional assays.
View Article and Find Full Text PDFPhysical exercise has an activating effect on platelet function that differs between trained and untrained subjects, depending on the type of exercise and training status. In humans, soluble P-selectin (sP-sel) and platelet-derived extracellular vesicles (PEVs) are considered reliable markers of platelet activation during exercise. In untrained humans, they increase after transient physical exercise, whereas long-term training induces a decrease in their resting levels due to an improved ability to adapt to hemodynamic changes.
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- Gestational diabetes mellitus (GDM) is linked to both immediate obstetric issues and long-term cardiovascular risks, but its effects on platelet function have been underexplored compared to type-2 diabetes.
- The study compared 23 women with GDM to 23 healthy pregnant women, measuring various aspects of platelet reactivity and endothelial function at different stages of pregnancy and postpartum.
- Results indicated that women with GDM had increased platelet hyperreactivity and activation, especially towards the end of pregnancy, with some abnormalities persisting up to 8 weeks after delivery, along with signs of endothelial dysfunction.
Training has a significant effect on the physiology of blood coagulation in humans and in horses. Several hemostatic changes have been reported after exercise in the horse but data available are inconclusive. The aim of this study was to investigate platelet activation and primary platelet-related hemostasis modifications in young never-trained Thoroughbreds in the first incremental training period in order to improve knowledge on this topic.
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