Atp1a2 and Kcnj9 Are Candidate Genes Underlying Sensitivity to Oxycodone-Induced Locomotor Activation and Withdrawal-Induced Anxiety-Like Behaviors in C57BL/6 Substrains.

Opioid use disorder is heritable, yet its genetic etiology is largely unknown. C57BL/6J and C57BL/6NJ mouse substrains exhibit phenotypic diversity in the context of limited genetic diversity which together can facilitate genetic discovery. Here, we found C57BL/6NJ mice were less sensitive to oxycodone (OXY)-induced locomotor activation versus C57BL/6J mice in a conditioned place preference paradigm.

The Interplay Between Stigma and Asian Cultural Values in People with Parkinson's Disease and Their Caregivers.

Parkinson's Disease (PD), the second most prevalent neurodegenerative disorder globally, often carries stigma for those affected; however, stigma's impact on PD caregivers is not well understood. This study investigates PD stigma and its interplay with cultural values, as well as explores the role of depressive symptomatology in shaping help-seeking attitudes among individuals with PD and the provision of support by PD caregivers. Using cross-sectional data collected from people living with PD and their caregivers, this study examines how adherence to Asian values influences the link between self-stigma and help-seeking tendencies in PD patients, as well as how affiliate stigma is linked to caregivers' willingness to help.

Study on pH-Responsive Delayed, Cross-Linking and Weighted Fracturing Fluid.

Hydraulic fracturing of deep, high-temperature reservoirs poses challenges due to elevated temperatures and high fracture pressures. Conventional polymer fracturing fluid (QCL) has high viscosity upon adding cross-linking agents and significantly increases wellbore friction. This paper examines a polymer fracturing fluid with pH response and low friction.

How socioeconomic and structural barriers influence dental care among transgender people.

Background: While recent US policies restrict access to healthcare and resulting health disparities among the transgender community, little is known about oral health access and utilization among this population. This study assessed self-reported access to dental care among transgender adults living in the United States.

Method: The study sample included 1,284,526 observations representing a weighted population of 290,000,163 from Behavioral Risk Factor and Surveillance Survey (BRFSS) datasets.

Comprehensive effects of sediment dredging on environmental risk and bioavailability of heavy metals from the sediment of Lake Taihu, China.

The comprehensive effects of environmental dredging on heavy metals (HM) are still uncertain. This study comprehensively evaluates the long-term effects of dredging on the environmental risk and bioavailability of HM (Cu, Ni, Zn, Pb, Cd, Cr, and As) in Lake Taihu, China, by comparing simulated dredged treated (D) and undredged (UD) sediment cores under in-situ conditions for one year. Threshold effect level (TEL), geological accumulation index (I), potential ecological risk index (RI), and ratios of secondary phase and primary phase (RSP) methods were used to assess the environmental risk of sediment HM; and the diffusive gradient in thin-films (DGT) technique was applied to assess the bioavailability of sediment HM.