Publications by authors named "E F Strong"

While large language models (LLMs) have shown promise in diagnostic reasoning, their impact on management reasoning, which involves balancing treatment decisions and testing strategies while managing risk, is unknown. This prospective, randomized, controlled trial assessed whether LLM assistance improves physician performance on open-ended management reasoning tasks compared to conventional resources. From November 2023 to April 2024, 92 practicing physicians were randomized to use either GPT-4 plus conventional resources or conventional resources alone to answer five expert-developed clinical vignettes in a simulated setting.

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Migraine affects 10% of adolescents and children. Typical school protocols in the USA require pharmacological medications to be administered by school nurses, often resulting in treatment delays or omissions when migraine attacks occur during school hours. The Remote Electrical Neuromodulation (REN) wearable is an FDA-cleared smartphone-controlled device delivering acute and preventive treatment of migraine attacks in patients aged 8 and above, allowing safe, effective, discreet, and independent usage.

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Article Synopsis
  • Drug-resistant Mycobacterium tuberculosis, especially mutants resistant to isoniazid, creates significant global health challenges due to mutations in the katG gene, affecting a crucial enzyme.
  • Researchers employed CRISPRi, transcriptomics, and metabolomics to identify metabolic and transcriptional changes in an isoniazid-resistant katG mutant, revealing new weaknesses in processes like respiration and ribosome biogenesis.
  • The study indicates that these identified vulnerabilities could be targeted for therapeutic strategies, offering potential improvements in treatment effectiveness against drug-resistant tuberculosis strains.
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Eyes within the marine gastropod superfamily Stromboidea range widely in size, from 0.2 to 2.3 mm - the largest eyes known in any gastropod.

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