Publications by authors named "E F Rosloniec"
Objective: The DRB1 locus is strongly associated with both susceptibility and resistance to rheumatoid arthritis (RA). DRB1 alleles encoding the VKA or VRA epitope in positions 11, 71 and 74 confer the highest risk of developing RA, while the allele encoding VEA is protective. We therefore investigated the feasibility of creating antigen-specific tolerance without inducing alloreactivity by replacing lysine with glutamic acid at position 71 in DRβ1*04:01.
View Article and Find Full Text PDFIntroduction And Objective: Low physical activity in patients with claudication is associated with lower walking abilities as assessed by the treadmill test. The impact of physical activity on the ability to walk in a natural environment is unknown. The study aimed to assess the level of daily physical activity among patients with claudication, as well as the relationship between the level of daily physical activity and claudication distance measured during the outdoor walking and treadmill tests.
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- Citrullination of proteins is important for protein function and immune responses, specifically in the context of autoimmune arthritis.
- In a study using HLA-DR1 transgenic mice, citrullinated collagen did not reduce arthritis severity, unlike native collagen which showed protective effects.
- The research indicates that citrullinated collagen may block the signaling pathway of a key inhibitory receptor (LAIR-1), suggesting a potential target for treating autoimmune arthritis by manipulating T-cell responses.
Article Synopsis
- The article focuses on corrections made to previously published research for accuracy and clarity.
- It highlights specific errors or omissions that were identified post-publication.
- The DOI reference helps locate the original article for context in academic discussions or references.
Vitamin D plays a crucial role in regulation of the immune response. However, treatment of autoimmune diseases with 1,25-dihydroxyvitamin D3 [1,25(OH)D3] doses sufficient to be effective is prohibitive due to its calcemic and toxic effects. We use the collagen-induced arthritis (CIA) model to analyze the efficacy of the noncalcemic analog of vitamin D, 20-hydroxyvitamin D3 [20(OH)D3], as well as 1,25(OH)D3, to attenuate arthritis and explore a potential mechanism of action.
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