Publications by authors named "E F Rose"

Intestinal ischemic injury damages the epithelial barrier predisposes patients to life-threatening sepsis unless that barrier is rapidly restored. There is an age-dependency of intestinal recovery in that neonates are the most susceptible to succumb to disease of the intestinal barrier versus older patients. We have developed a pig model that demonstrates age-dependent failure of intestinal barrier restitution in neonatal pigs which can be rescued by the direct application of juvenile pig mucosal tissue, but the mechanisms of rescue remain undefined.

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Human adenoviruses (HAdVs) are typically associated with mild respiratory illnesses, although severe disease and outbreaks in congregate settings occur. The National Adenovirus Type Reporting System (NATRS) is a passive, laboratory-based surveillance system that monitors trends in circulation of HAdV types in the United States. This report summarizes the distribution of HAdV types reported to NATRS during 2017-2023.

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Article Synopsis
  • The study investigates how bone marrow-derived pro-inflammatory macrophages and embryo-derived reparative macrophages impact progressive heart failure with reduced ejection fraction (HFrEF) and explores the potential of mesenchymal precursor cells (MPCs) to improve patient outcomes.
  • In the DREAM-HF trial, significant risk factors for cardiovascular death (CVD) were identified in patients with HFrEF, particularly inflammation and ischaemic aetiology, which increased the risk by 61% and 38%, respectively.
  • The introduction of MPCs led to notable reductions in major adverse cardiovascular events (MACE) by 88% and 52% over a 30-month follow-up in patients with ischaemic HFrEF and inflammation.
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Transcriptome analysis has become a central tool in evolutionary and functional genomics. However, variation among biological samples and analysis techniques can greatly influence results, potentially compromising insights into the phenomenon under study. Here, we evaluate differences in the brain transcriptome between female and male Gulf pipefish (Syngnathus scovelli).

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