Publications by authors named "E F Pratt"
Purpose: Recent clinical advances with the approval of antibody-drug conjugates targeting Trop-2 such as sacituzumab-govitecan and datopotomab-deruxtecan have garnered tremendous interest for their therapeutic efficacy in numerous tumor types including breast and lung cancers. ImmunoPET can stratify tumor avidity, clarifying patient eligibility for ADC therapy as well as a diagnostic companion during therapy. Slow antibody circulation requires days to reach optimal imaging timepoints.
View Article and Find Full Text PDFArticle Synopsis
- Common sampling methods for sows, like serum and tonsil scraping, raise animal welfare concerns and can be labor-intensive; the innovative Tonsil-Oral-Scrubbing (TOSc) collector allows easier and quicker fluid retrieval without snaring the animals.* -
- A field study was conducted to compare detection rates of porcine reproductive and respiratory syndrome virus (PRRSV) RNA in four sample types (TOSc, serum, oral fluids, and tonsil scraping) at different time points after live-virus inoculation in 61 sows.* -
- Results showed that tonsil scraping had the highest PRRSV RNA positivity, while TOSc also performed well compared to oral fluids and serum; however, both TOSc
In 2021, the World Health Organization classified isocitrate dehydrogenase () mutant gliomas as a distinct subgroup of tumors with genetic changes sufficient to enable a complete diagnosis. Patients with an mutant glioma have improved survival which has been further enhanced by the advent of targeted therapies. enzymes contribute to cellular metabolism, and mutations to specific catalytic residues result in the neomorphic production of D-2-hydroxyglutarate (D-2-HG).
View Article and Find Full Text PDFIdentifying cancer therapy resistance is a key time-saving tool for physicians. Part of chemotherapy resistance includes senescence, a persistent state without cell division or cell death. Chemically inducing senescence with the combination of trametinib and palbociclib (TP) yields several tumorigenic and prometastatic factors in pancreatic cancer models with many potential antibody-based targets.
View Article and Find Full Text PDFDecades of research have shown that magnetocardiography (MCG) has the potential to improve cardiac care decisions. However, sensor and system limitations have prevented its widespread adoption in clinical practice. We report an MCG system built around an array of scalar, optically pumped magnetometers (OPMs) that effectively rejects ambient magnetic interference without magnetic shielding.
View Article and Find Full Text PDF