Sickle cell disease associated with thalassemia; description of a rare mutation.

Sickle cell disease (SCD) is a common hemoglobinopathy, secondary to alterations in the β globin chain, resulting in an abnormal hemoglobin variant named as hemoglobin S. These disorders show a wide phenotypical spectrum, and the prevalence of these disorders has significantly changed over the time because of multiple factors such as migration. We report a case of a 17-year-old black male, born in Gambia, diagnosed with sickle cell disease, who presented an associated mutation only described in a Japanese family (Oshima et al.

Towards Sustainable Energy-Efficient Communities Based on a Scheduling Algorithm.

The Internet of Things (IoT) and Demand Response (DR) combined have transformed the way Information and Communication Technologies (ICT) contribute to saving energy and reducing costs, while also giving consumers more control over their energy footprint. Unlike current price and incentive based DR strategies, we propose a DR model that promotes consumers reaching coordinated behaviour towards more sustainable (and green) communities. A cooperative DR system is designed not only to bolster energy efficiency management at both home and district levels, but also to integrate the renewable energy resource information into the community's energy management.

Component-Based Modelling for Scalable Smart City Systems Interoperability: A Case Study on Integrating Energy Demand Response Systems.

Smart city systems embrace major challenges associated with climate change, energy efficiency, mobility and future services by embedding the virtual space into a complex cyber-physical system. Those systems are constantly evolving and scaling up, involving a wide range of integration among users, devices, utilities, public services and also policies. Modelling such complex dynamic systems' architectures has always been essential for the development and application of techniques/tools to support design and deployment of integration of new components, as well as for the analysis, verification, simulation and testing to ensure trustworthiness.