Publications by authors named "E F Mongodin"
Article Synopsis
- Lyme disease, caused by spirochete bacteria transmitted by ticks, is the most common and rapidly spreading tick-borne illness in Europe and North America.
- Researchers sequenced the genomes of 47 Lyme disease isolates, revealing a diverse range of species and consistent plasmid features that are crucial for the bacteria's adaptation.
- The study highlights the genetic complexities involved, such as recombination and rapid evolution, especially in genes that interact with hosts, contributing to the bacteria's virulence while maintaining a mostly clonal population structure.
Article Synopsis
- Tobacco use alters the oral microbiome, affecting the diversity and abundance of bacterial communities in smokers and smokeless tobacco users compared to non-users over a 4-month period.
- Cigarette and smokeless tobacco users showed a higher diversity of bacteria, with more Firmicutes and fewer Proteobacteria, while non-users had more beneficial genera like Actinomyces and Neisseria.
- Some bacterial species shifted significantly over time, and opportunistic pathogens were identified in tobacco users, providing new insights into the oral health impacts of different tobacco products.
Background: Despite ongoing improvements to regimens preventing allograft rejection, most cardiac and other organ grafts eventually succumb to chronic vasculopathy, interstitial fibrosis, or endothelial changes, and eventually graft failure. The events leading to chronic rejection are still poorly understood and the gut microbiota is a known driving force in immune dysfunction. We previously showed that gut microbiota dysbiosis profoundly influences the outcome of vascularized cardiac allografts and subsequently identified biomarker species associated with these differential graft outcomes.
View Article and Find Full Text PDFBackground: Chemotherapy is a primary treatment for cancer, but its efficacy is often limited by cancer-associated bacteria (CAB) that impair tumor suppressor functions. Our previous research found that Mycoplasma fermentans DnaK, a chaperone protein, impairs p53 activities, which are essential for most anti-cancer chemotherapeutic responses.
Methods: To investigate the role of DnaK in chemotherapy, we treated cancer cell lines with M.
Intrinsic metabolism shapes the immune environment associated with immune suppression and tolerance in settings such as organ transplantation and cancer. However, little is known about the metabolic activities in an immunosuppressive environment. In this study, we employed metagenomic, metabolomic, and immunological approaches to profile the early effects of the immunosuppressant drug tacrolimus, antibiotics, or both in gut lumen and circulation using a murine model.
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