Embryonic Zebrafish Irritant-evoked Hyperlocomotion (EZIH) as a high-throughput behavioral model for nociception.

Behavioral models have served a key role in understanding nociception, the sensory system by which animals detect noxious stimuli in their environment. Developing zebrafish (Danio rerio) are a powerful study organism for examining nociceptive pathways, given the vast array of genetic, developmental, and neuroscience tools available for these animals. However, at present there are few widely-adopted behavioral models for nociception in developing zebrafish.

Perspectives on Using Artificial Intelligence to Derive Social Determinants of Health Data From Medical Records in Canada: Large Multijurisdictional Qualitative Study.

Background: Data on the social determinants of health could be used to improve care, support quality improvement initiatives, and track progress toward health equity. However, this data collection is not widespread. Artificial intelligence (AI), specifically natural language processing and machine learning, could be used to derive social determinants of health data from electronic medical records.

Interpersonal relationships after prenatal diagnosis of congenital heart disease: Social stressors and supports.

Objective: To identify social stressors and supports for expectant parents after prenatal diagnosis of congenital heart disease (CHD) and inform interventions to reduce distress.

Method: Parents of children diagnosed prenatally with CHD (N = 37) were purposively sampled across eight health systems. Qualitative data were collected using crowdsourcing methods and coded/analyzed using thematic analysis.

Examining experiences and system impacts of publicly funded episodic virtual care: protocol for a cross-provincial mixed methods study.

Introduction: Health systems are under pressure as one in five Canadians have no regular place for primary care, with many experiencing substantial travel times and delays in accessing care. In the context of these urgent needs, platforms for virtual care offer immediate access to care in 'walk-in' style format, with limited continuity for ongoing health needs or coordination with other health services. We refer to these services as episodic virtual care (EVC), to distinguish them from virtual services offered in longitudinal primary care.

EPAS1 induction drives myocardial degeneration in desmoplakin-cardiomyopathy.

Arrhythmogenic cardiomyopathy (ACM) is frequently attributed to desmosomal mutations, such as those in the desmoplakin () gene. Patients with DSP-cardiomyopathy are predisposed to myocardial degeneration and arrhythmias. Despite advancements, the underlying molecular mechanisms remain incompletely understood, thus limiting therapeutic options.