Succinyl Chitosan-Colistin Conjugates as Promising Drug Delivery Systems.

The growth of microbial multidrug resistance is a problem in modern clinical medicine. Chemical modification of active pharmaceutical ingredients is an attractive strategy to improve their biopharmaceutical properties by increasing bioavailability and reducing drug toxicity. Conjugation of antimicrobial drugs with natural polysaccharides provides high efficiency of these systems due to targeted delivery, controlled drug release and reduced toxicity.

Novel D-A-π-A1 Type Organic Sensitizers from 4,7-Dibromobenzo[][1,2,3]thiadiazole and Indoline Donors for Dye-Sensitized Solar Cells.

Two novel D-A-π-A1 metal-free organic dyes of the series containing benzo[][1,2,3]thiadiazole (isoBT) internal acceptor, indoline donors fused with cyclopentane or cyclohexane rings (D), a thiophene as a π-spacer, and a cyanoacrylate as an anchor part were synthesized. Monoarylation of 4,7-dibromobenzo[][1,2,3]thiadiazole by Suzuki-Miyamura cross-coupling reaction showed that in the case of indoline and carbazole donors, the reaction was non-selective, i.e.

Hyaluronan-colistin conjugates: Synthesis, characterization, and prospects for medical applications.

The development of nanotechnology-based antibiotic delivery systems (nanoantibiotics) is an important challenge in the effort to combat microbial multidrug resistance. These systems have improved biopharmaceutical characteristics by increasing local bioavailability and reducing systemic toxicity and the number and frequency of drug side effects. Conjugation of low -molecular -weight antibacterial agents with natural polysaccharides is an effective strategy for developing optimal targeted delivery systems with programmed release and reduced cytotoxicity.

Hybrid Nanoparticles and Composite Hydrogel Systems for Delivery of Peptide Antibiotics.

The growing number of drug-resistant pathogenic bacteria poses a global threat to human health. For this reason, the search for ways to enhance the antibacterial activity of existing antibiotics is now an urgent medical task. The aim of this study was to develop novel delivery systems for polymyxins to improve their antimicrobial properties against various infections.

Benzothiadiazole vs. -Benzothiadiazole: Synthesis, Electrochemical and Optical Properties of D-A-D Conjugated Molecules Based on Them.

This paper presents an improved synthesis of 4,7-dibromobenzo[][1,2,3]thiadiazole from commercially available reagents. According to quantum-mechanical calculations, benzo[][1,2,3]thiadiazole (isoBTD) has higher values of E and energy band gap (E), which indicates high electron conductivity, occurring due to the high stability of the molecule in the excited state. We studied the cross-coupling reactions of this dibromide and found that the highest yields of π-spacer-acceptor-π-spacer type compounds were obtained by means of the Stille reaction.