Publications by authors named "E F Kikkawa"
Background: The human induced pluripotent stem cells (hiPSCs) can generate all the cells composing the human body, theoretically. Therefore, hiPSCs are thought to be a candidate source of stem cells for regenerative medicine. The major challenge of allogeneic hiPSC-derived cell products is their immunogenicity.
View Article and Find Full Text PDFThe most important prognostic factor for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) is minimal residual disease (MRD). Previous studies have reported copy number variants of genes such as , , and . These gene mutations can be analyzed using multiplex ligation-dependent probe amplification (MLPA), which is less costly and easier to perform than large-scale gene mutation analyses.
View Article and Find Full Text PDFCord blood stem cell transplantation is an important alternative for patients needing hematopoietic stem cell transplantation. However, it is unclear how cord blood cells, which are 0 years old, age in the recipient's body after allogeneic transplantation. We performed DNA methylation (DNAm) age analysis to measure the age of cells using post-transplant peripheral blood in 50 cases of cord blood transplantation.
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- The study investigates the relationship between fetal hemoglobin (HbF) levels and prognosis in patients with myelodysplastic syndrome (MDS), analyzing data from 217 diagnosed patients.
- HbF levels were found to be higher in MDS patients compared to a control group, with lower-risk patients showing longer leukemia-free survival (LFS) at intermediate HbF levels.
- The research concludes that intermediate HbF levels may be linked to better outcomes in lower-risk MDS patients, highlighting the importance of HbF in MDS prognosis according to recent WHO criteria.
Mitochondria are indispensable in maintaining hematopoietic stem cells (HSCs), and mitochondrial complex II (MCII) has been recognized as a key component of HSCs. However, the physiological role of MCII on long-term hematopoiesis and hematopoietic reconstitution capacity remains unknown. Hence, this study evaluated the impact of MCII dysfunctions on long-term HSC maintenance and hematopoietic homeostasis among conditional transgenic mice with a missense mutation in the succinate dehydrogenase complex subunit C gene (SdhcV69E).
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