Publications by authors named "E F Ferraro"
Introduction: Cardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is multi-factorial, meaning identification of effective treatments has been limited. The antifibrotic effect of the bile acid ursodeoxycholic acid (UDCA) is established in cases of liver fibrosis however its mechanism and role in cardiac fibrosis is less well understood.
View Article and Find Full Text PDFArticle Synopsis
- Highly pathogenic H5N1 (HP H5N1) influenza A virus has been found in North American ducks since 2021, leading to a study monitoring blue-winged teal in the Mississippi flyway from spring 2022 to spring 2024 for infection and antibody levels.
- The research revealed peak infections in fall 2022 in Minnesota, mirroring historic patterns seen with low-pathogenicity influenza A viruses, but with a notably higher prevalence of H5N1.
- Results indicated a shift in antibody response over the study period, with more ducks testing positive for the specific H5 antigen of the HP H5N1 strain, suggesting evolving patterns in how the virus is affecting duck populations during migration.
Article Synopsis
- * Of the 269 patients with RD, 64% were still HER2(+) while 36% had lost HER2 positivity; both subgroups had similar rates of invasive breast cancer recurrence and brain metastasis events during a 24-month follow-up.
- * Overall, higher IDFS (invasive disease-free survival) events were observed in patients with RD compared to those who achieved a pathologic complete response (pCR), indicating that further effective treatment strategies are needed to reduce the
Article Synopsis
- The study investigates the effects of discontinuing dimethyl fumarate (DMF) during early pregnancy in women with multiple sclerosis (MS), analyzing 137 pregnancies from Italian MS Centers.
- Results show that disease activity typically decreases during pregnancy but increases postpartum; higher relapse rates before conception correlate with faster relapses after giving birth.
- Importantly, DMF exposure during early pregnancy did not negatively affect fetal outcomes, suggesting it is safe for the pregnancy context.
The co-occurrence of germline and somatic oncogenic alterations is frequently observed in breast cancer, but their combined biologic and clinical significance has not been evaluated. To assess the role of germline-somatic interactions on outcomes in routine practice, we developed an integrated clinicogenomic pipeline to analyze the genomes of over 4,500 patients with breast cancer. We find that germline (g) -associated tumors are enriched for loss-of-function mutations and manifest poor outcomes on standard-of-care, front-line CDK4/6 inhibitor (CDK4/6i) combinations.
View Article and Find Full Text PDF