[The effect of influenza virus hemagglutinin on erythrocytes and thrombocytes].

We studied the effect of influenza virus hemagglutinin on the volume of erythrocytes and aggregation activity of thrombocytes. Hemagglutinin proved to increase the erythrocyte volume, which ends in their lysis, and to induce disaggregation of the thrombocytes. The effect of hemagglutinin on the erythrocytes and thrombocytes was dose-dependent.

[The effect of a toxic dose of ammonium chloride on brain bioelectrical activity in rats].

A toxic dose of ammonium chloride (> 12 mmol/kg) caused death of animals within 10 min of i.p. injection, while pentobarbital--(40 mg/kg, i.

Switch on and switch off phenomenon of liver gluconeogenic function in lamprey (Lampetra fluviatilis L.) under the influence of season and temperature.

The potential activity of pyruvate carboxylase in lamprey liver is the same as in mammals. However, at certain stages of the life cycle this reaction does not take place because of ATP deficiency in mitochondria. Energy charge potential of liver cells ranges from 0.

[Effect of bicarbonate and insulin on the mitochondria-cytoplasmic interactions in the rat liver in vivo].

An inhibitory effect of bicarbonate, administered into rats, on gluconeogenesis within the first 30 min was due to inactivation of the tricarboxylic acid cycle and to deficiency of ATP. Impairment of mitochondrial functions during this period was accompanied by alterations in transport of metabolites, in gluconeogenesis and in turnover of fatty- and amino acids. Insulin prevented mainly these deteriorations but it was also responsible for a specific effect--an increase in gluconeogenesis inhibition during the subsequent period, inhibition of ADP transport from cytosol to mitochondria.

[Effect of bicarbonate and insulin on energy metabolism in the mitochondria of rat liver].

Administration of physiologically low doses of bicarbonate into rats caused an inhibition of oxidative phosphorylation and a transitory decrease in ATP content in liver mitochondria; at the same time, concentrations of malate and glutamate were unaltered and those of pyruvate and phosphoenolpyruvate were decreased. Insulin removed the bicarbonate effect on mitochondrial functions but affected only slightly the distribution of metabolites. Bicarbonate appears to activate pyruvate carboxylase and to inhibit succinate dehydrogenase as well as the operation of tricarboxylic acid cycle due to accumulation of oxaloacetate.