System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans.

We performed a systems vaccinology analysis to investigate immune responses in humans to an H5N1 influenza vaccine, with and without the AS03 adjuvant, to identify factors influencing antibody response magnitude and durability. Our findings revealed a platelet and adhesion-related blood transcriptional signature on day 7 that predicted the longevity of the antibody response, suggesting a potential role for platelets in modulating antibody response durability. As platelets originate from megakaryocytes, we explored the effect of thrombopoietin (TPO)-mediated megakaryocyte activation on antibody response longevity.

ProPickML: Advancing Clinical Diagnostics with Automated Peak Picking in Label-Free Targeted Proteomics.

In targeted proteomics utilizing Selected Reaction Monitoring (SRM), the precise detection of specific peptides within complex mixtures remains a significant challenge, particularly due to noise and interference in chromatograms. Existing methodologies, such as isotopic labeling and scoring algorithms, offer partial solutions but are constrained by high run times and elevated false discovery rates. To address these limitations, we have developed ProPickML a machine learning-based tool designed to accurately identify peptide peaks across diverse data sets, independent of the assumed presence of the peptide.

Association of Emotional Intelligence With Pharmacy Students' Leadership and Academic Performance.

Objective: This study aimed to examine the association between emotional intelligence, leadership involvement, and academic performance among student pharmacists.

Methods: This was a retrospective, observational study that included all second-year student pharmacists in the 2022-2023 and 2023-2024 academic years. Emotional intelligence was assessed using the emotional quotient (EQ) inventory, version 2.

Economic cost-benefit analysis of person-centred medicines reviews by general practice pharmacists.

Background: Medicines reviews by general practice pharmacists improve patient outcomes, but little is known about the associated economic outcomes, particularly in patients at higher risk of medicines-related harm.

Aim: To conduct an economic cost-benefit analysis of pharmacists providing person-centred medicines reviews to patients with hyperpolypharmacy (prescribed ≥ 10 regular medicines) and/or at high risk of medicines-related harm across multiple general practice settings.

Method: Service delivery costs were calculated based on the pharmacist's salary, recorded timings, and a general practitioner fee.

Seasonal extreme temperatures and short-term fine particulate matter increases pediatric respiratory healthcare encounters in a sparsely populated region of the intermountain western United States.

Background: Western Montana, USA, experiences complex air pollution patterns with predominant exposure sources from summer wildfire smoke and winter wood smoke. In addition, climate change related temperatures events are becoming more extreme and expected to contribute to increases in hospital admissions for a range of health outcomes. Evaluating while accounting for these exposures (air pollution and temperature) that often occur simultaneously and may act synergistically on health is becoming more important.