Publications by authors named "E F Brachtel"
Article Synopsis
- Fine-needle aspiration (FNA) is a less common but important diagnostic method for breast lesions, and this study evaluates its effectiveness compared to core needle biopsies.
- A review of 65 FNA cases revealed that while some results were insufficient or atypical, FNA demonstrated high sensitivity (76%) and specificity (96%) for detecting malignancy, with some false negatives and one false positive identified.
- The findings suggest that FNA remains a valuable diagnostic approach, especially for cystic lesions, and should continue to be used alongside imaging and clinical evaluation in breast lesion assessments.
Background: Multiple clinical trials demonstrate consistent but modest benefit of adjuvant extended endocrine therapy (EET) in HR + breast cancer patients. Predictive biomarkers to identify patients that benefit from EET are critical to balance modest reductions in risk against potential side effects of EET. This study compares the performance of the Breast Cancer Index, BCI (HOXB13/IL17BR, H/I), with expression of estrogen (ER), progesterone (PR), and androgen receptors (AR), and Ki67, for prediction of EET benefit.
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- * In a study of 2,445 patients, those with a high BCI (H/I) ratio showed significant improvement in recurrence-free interval with extended tamoxifen, while those with low ratios did not.
- * The analysis revealed that BCI (H/I) serves as a crucial biomarker for determining treatment effectiveness, specifically for HR+ patients who are lymph node-positive and HER2-negative.
Purpose: Young age at breast cancer diagnosis correlates with unfavorable clinicopathologic features and worse outcomes compared with older women. Understanding biological differences between breast tumors in young versus older women may lead to better therapeutic approaches for younger patients.
Experimental Design: We identified 100 patients ≤35 years old at nonmetastatic breast cancer diagnosis who participated in the prospective Young Women's Breast Cancer Study cohort.