Publications by authors named "E F Attia"
Cancers still globally endanger millions of people yearly; the incidences/mortalities of colorectal cancers are particularly increasing. The natural nanoparticles (NPs) and marine biopolymers were anticipated to provide effectual safe significances for managing cancers. The transformation of curcumin to nano-curcumin (NCur) was conducted with gum Arabic.
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- The ethyl acetate extract from the endophytic fungus Aspergillus terreus found in Artemisia arborescens L. led to the discovery of five new compounds, asperterreunolides A-E, along with a known metabolite, butyrolactone IV.
- Using advanced spectroscopic techniques, the researchers determined the structures and the absolute configurations of these metabolites.
- All isolated compounds exhibited significant cytotoxic effects against certain cancer cell lines, and molecular docking studies suggested their potential mechanism of action as inhibitors of type IIA topoisomerase.
Article Synopsis
- Findings indicate that higher cumulative HIV viral load (VL) and lower CD4 cell counts are significantly linked to an increased risk of developing venous thromboembolism (VTE) in people living with HIV (PWH).
- A study involving over 21,000 PWH over nearly five years revealed that those with higher cumulative VL had a 45% increased risk of VTE compared to those with lower VL. Additionally, a CD4 count below 100 cells/mm³ was associated with a fourfold increase in risk.
- The research suggests that managing HIV viral load and maintaining CD4 levels could be crucial strategies to lower the risk of VTE in PWH.
Background: In children, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon subtype of Hodgkin lymphoma. Given the lack of data on the best chemotherapy regimen, there is a knowledge gap in best management.
Methods: This retrospective study included all pediatric patients with NLPHL diagnosed and treated at the Children's Cancer Hospital, Egypt (2007-2018).