Publications by authors named "E Exposito"
Article Synopsis
- Microscopic colitis (MC) and celiac disease (CD) are two chronic inflammatory conditions involving the colon and small bowel, respectively, with recent studies revealing a significant prevalence of both disorders coexisting in about 6% of refractory cases.
- Both conditions display shared characteristics, including common risk factors, autoimmunity, and similar symptoms, while still maintaining some distinct differences.
- More research is required to unravel the intricate mechanisms that link these diseases and clarify their epidemiological relationship.
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder linked to intestinal barrier dysfunction and life stress. We have previously reported that female sex per se determines an increased susceptibility to intestinal barrier dysfunction after cold pain stress (CPS). We aimed to identify sex-related molecular differences in response to CPS in healthy subjects to understand the origin of sex bias predominance in IBS.
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- IBS (Irritable Bowel Syndrome) is a condition characterized by abdominal pain and varying bowel habits, particularly focusing on the diarrhea subtype (IBS-D), which shows changes in gut barrier and immune responses.
- A study analyzed jejunal biopsies and stool samples from both IBS-D patients and healthy controls, measuring factors like plasma cell activation, nerve proximity, and glycocalyx thickness, finding notable differences in humoral immune pathways.
- Results indicated that IBS-D patients had heightened plasma cell activity and lower glycocalyx thickness, linking these factors to gut dysfunction and clinical symptoms, suggesting the need for further research to clarify the mechanisms involved.
There is converging and increasing evidence, but also uncertainty, for the role of abnormal intestinal epithelial barrier function in the origin and development of a growing number of human gastrointestinal and extraintestinal inflammatory disorders, and their related complaints. Despite a vast literature addressing factors and mechanisms underlying changes in intestinal permeability in humans, and its connection to the appearance and severity of clinical symptoms, the ultimate link remains to be established in many cases. Accordingly, there are no directives or clinical guidelines related to the therapeutic management of intestinal permeability disorders that allow health professionals involved in the management of these patients to carry out a consensus treatment based on clinical evidence.
View Article and Find Full Text PDFIOTA is a distributed ledger technology (DLT) platform proposed for the internet of things (IoT) systems in order to tackle the limitations of Blockchain in terms of latency, scalability, and transaction cost. The main concepts used in IOTA to reach this objective are a directed acyclic graph (DAG) based ledger, called Tangle, used instead of the chain of blocks, and a new validation mechanism that, instead of relying on the miners as it is the case in Blockchain, relies on participating nodes that cooperate to validate the new transactions. Due to the different IoT capabilities, IOTA classifies these devices into full and light nodes.
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