A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib.

Most of the somatic epidermal growth factor receptor (EGFR) mutations described to date in non-smallcell lung cancer (NSCLC) patients are located in the kinase domain and are considered activating mutations. Some of these mutations are associated with response to specific EGFR tyrosine kinase inhibitors (TKI) such as gefitinib and erlotinib. Here we report a case of a previously undescribed EGFR nonsense mutation in a lung adenocarcinoma patient who did not derive any clinical benefit with combination chemotherapy and erlotinib.

Elliptic incoherent solitons in saturable nonlinear media.

We identify elliptic incoherent spatial solitons in isotropic saturable nonlinear media. These solitary states are possible, provided that their correlation function is anisotropic. The propagation dynamics of this new class of solitons are investigated by use of numerical simulations.

Design of switching junctions for two-dimensional discrete soliton networks.

The performance of switching junctions in two-dimensional discrete-soliton networks is analyzed theoretically by coupled-mode theory. Our analysis can be used for the design of routing junctions with specified operational characteristics. Appropriately engineering the intersection site can further improve the switching efficiency of these junctions.

Minimizing bending losses in two-dimensional discrete soliton networks.

We show that reflection losses suffered by discrete solitons along sharp bends in two-dimensional waveguide-array networks can be almost eliminated. Analysis indicates that this can be accomplished by appropriately engineering the corner site of the bend. Our analytical results are verified by numerical simulations.

Self-trapping of bright rings.

We present experimental observations of self-trapped rings carrying zero topological charge, along with simulations that display the self-focusing dynamics of the rings and their stability features in materials with saturable nonlinearities.