Pharmacologically induced absence seizures kindling in Wistar rats.

Objective: This study aimed to investigate the effects of γ-butyrolactone (GBL), a prodrug of gamma-Hydroxybutyric acid -induced absence seizures on the development of kindling in Wistar rats.

Methods: Three groups of adult male Wistar rats under anesthesia were implanted with bilateral cortical recording electrodes for the GBL group (GBL) and/or bipolar stimulation electrodes into the right basolateral amygdala for the Kindling group (KI) alone and Kindling plus GBL group (GBL+KI). Rats in the KI and GBL+KI groups were stimulated twice daily at the afterdischarge threshold until they reached Racine's stage 5 seizure state.

Secondary Infections in Febrile Neutropenia in Hematological Malignancies: More Than Another Febrile Neutropenic Episode.

Introduction: Febrile neutropenic episodes (FNEs) are among major causes of mortality in patients with hematological malignancies. Secondary infections develop either during the empirical antibiotic therapy or one week after cessation of therapy for a FNE. The aim of the study was to investigate the risk factors associated with secondary infections in febrile neutropenic patients.

[THE NASCENCY OF DRUG AND FIRST STEPS OF ITS DEVELOPMENT].

In this historical review article, the first examples of human attempts to use drugs for the solution of their health problems and the development of the concept of natural toxic (poisonous) substances in the history and prehistoric times, are discussed. It is regarded that, outside of the quelling of the hunger or quenching the thirst, some of our early an- cestors have coincidentally began to distinguish the different effects in some of the natural products in their environment, probably during their nutritional behavior. It is thought that in this way, the awareness for drugs and toxic substances have been raised.

The effect of oral and subcutaneous meperidine on the maximal electroshock seizure (MES) in mice.

The likely effect of oral and subcutaneous meperidine on maximal electroshock seizure (MES) in mice was studied. Convulsive current fifty (CC50) was assessed to be 46m A, an electrical pulse causing seizure in 50% of test animals. Doses of 15, 30, 60, or 120 mg/kg meperidine given orally or subcutaneously increased the convulsion threshold of MES as evidenced by a significant dose-dependent reduction of MES below control value (p < .

Resistance to propagation of amygdaloid kindling seizures in rats with genetic absence epilepsy.

Purpose: The existence of absence epilepsy and temporal partial seizure pattern in the same patient is an uncommon state. In the present study, we aimed to evaluate whether the process of kindling as a model of complex partial seizures with secondary generalization is altered in rats with genetic absence epilepsy.

Methods: Six- to 12-month-old nonepileptic control Wistar rats and genetic absence epileptic rats from Strasbourg (GAERS) were used in the experiments.