Publications by authors named "E Erik Jan de Heide"
Article Synopsis
- This study investigates white matter (WM) changes in newly diagnosed epilepsy patients who had a first seizure, focusing on differences in WM integrity compared to healthy controls using diffusion imaging.
- Results showed that first-seizure patients exhibited decreased fractional anisotropy (FA) in specific brain areas, including the corpus callosum, indicating microstructural abnormalities even before a formal epilepsy diagnosis.
- The findings suggest that patients who go on to develop epilepsy show distinct WM alterations compared to those who do not, highlighting the significance of early brain changes in the epileptogenic process.
Article Synopsis
- * Our research identified four types of sonic ambiances (Comfortable, Pleasurable, Motivating, Stimulating) and established design parameters to create these through sound.
- * The study found a strong link between the pleasantness of soundscapes and listener pleasure, plus a moderate link between eventfulness and arousal, suggesting a need-driven approach could effectively support ICU patients.
Background: COVID-19 confronted medical care with many challenges. During the pandemic, several resources were limited resulting in renouncing or postponing medical care like carotid endarterectomy (CEA) for patients with significant carotid artery stenosis. Although according to international guidelines CEA is the first choice, carotid artery stenting (CAS) could potentially be a reasonable alternative especially during logistical restraints.
View Article and Find Full Text PDFAcute myeloid leukemia (AML) is a heterogeneous disease characterized by genomic aberrations in oncogenes, cytogenetic abnormalities, and an aberrant epigenetic landscape. Nearly 50% of AML cases will relapse with current treatment. A major source of therapy resistance is the interaction of mesenchymal stroma with leukemic cells resulting in therapeutic protection.
View Article and Find Full Text PDFPurpose: Chronic inflammation is integral to myeloproliferative neoplasm (MPN) pathogenesis. JAK inhibitors reduce cytokine levels, but not without significant side effects. Nutrition is a low-risk approach to reduce inflammation and ameliorate symptoms in MPN.
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