Publications by authors named "E Enzo"
The complex network governing self-renewal in epidermal stem cells (EPSCs) is only partially defined. FOXM1 is one of the main players in this network, but the upstream signals regulating its activity remain to be elucidated. In this study, we identify cyclin-dependent kinase 1 (CDK1) as the principal kinase controlling FOXM1 activity in human primary keratinocytes.
View Article and Find Full Text PDFA cellular disease model toward gene therapy of -dependent lamellar ichthyosis.
Mol Ther Methods Clin Dev
September 2024
Lamellar ichthyosis (LI) is a chronic disease, mostly caused by mutations in the gene, marked by impaired skin barrier formation. No definitive therapies are available, and current treatments aim at symptomatic relief. LI mouse models often fail to faithfully replicate the clinical and histopathological features of human skin conditions.
View Article and Find Full Text PDFArticle Synopsis
- JAK2V617F is the most common genetic mutation in Philadelphia-negative chronic Myeloproliferative Neoplasms (MPNs), and researchers believe abnormalities in Chromosome 9 may influence the disease in patients with this mutation.
- A specific group of MPN patients, called +9p patients, were found to have three copies of the JAK2 gene and nearby genes, leading to increased production of the immunosuppressive PD-L1 protein.
- The study showed that these +9p patients have a distinct cancer profile, characterized by greater stem cell-like properties and an immune response that results in exhausted T cells, highlighting a complex interaction between +9p and JAK2V617F mutations.
Epidermal stem cells (EPSCs) are essential for maintaining skin homeostasis and ensuring a proper wound healing. During in vitro cultivations, EPSCs give rise to transient amplifying progenitors and differentiated cells, finally forming a stratified epithelium that can be grafted onto patients. Epithelial grafts have been used in clinics to cure burned patients or patients affected by genetic diseases.
View Article and Find Full Text PDFEpidermal stem cells orchestrate epidermal renewal and timely wound repair through a tight regulation of self-renewal, proliferation, and differentiation. In culture, human epidermal stem cells generate a clonal type referred to as holoclone, which give rise to transient amplifying progenitors (meroclone and paraclone-forming cells) eventually generating terminally differentiated cells. Leveraging single-cell transcriptomic data, we explored the FOXM1-dependent biochemical signals controlling self-renewal and differentiation in epidermal stem cells aimed at improving regenerative medicine applications.
View Article and Find Full Text PDF