Individualized Cell-Free DNA Monitoring With Chromosomal Junctions for Mesothelioma.

Introduction: The spatially complex nature of mesothelioma and interventions like pleurodesis, surgery, and radiation often complicate imaging-based assessment. Further, cell-free DNA (cfDNA) based monitoring strategies are inadequate for mesothelioma, given the presence of a few recurring nonsynonymous somatic variants. However, patient-specific chromosomal rearrangements are commonly found in mesothelioma.

A rare cause of dyspnea on exertion with a cardiopulmonary exercise stress test.

Background: It is rare for an adult patient to be living decades after a pneumonectomy procedure. This case features complications that can arise. We utilize cardiopulmonary exercise stress testing (CPET) to highlight long-term physiologic changes that can present in a post-pneumonectomy patient.

Age and Menopausal Status in Idiopathic Subglottic Stenosis.

Objective: To evaluate the impact of age on disease recurrence in idiopathic subglottic stenosis (iSGS) patients.

Methods: This was a retrospective chart review of iSGS patients treated with laser wedge excision. Patients did not have prior surgery.

Methotrexate and Rituximab Use in Highly Recurrent Idiopathic Subglottic Stenosis.

Objective: To evaluate the impact of methotrexate and rituximab therapy on highly recurrent idiopathic subglottic stenosis (iSGS) patients with a negative antineutrophil cytoplasmic antibody titer cANCA(-).

Methods: This was a retrospective cohort study of highly recurrent iSGS patients who recurred within 1 year or less and were treated with methotrexate (MTX), and rituximab (RTX), or a combination of both at different time points (MTX/RTX). Average surgical durations before and after drug treatment were summarized, and the differences were calculated.

A Retrospective Evaluation of the Treatment Effects of Rituximab in Patients with Progressive and Symptomatic Fibrosing Mediastinitis.

Fibrosing mediastinitis (FM) is an uncommon fibroinflammatory condition without established or effective medical therapies. Infiltrating B lymphocytes are commonly present, and progressive fibrosis compromises mediastinal structures, including blood vessels and airways, resulting in significant morbidity and mortality. To evaluate the benefits and side effects of rituximab in patients with progressive and symptomatic FM.