Effects of the Mammalian Target of Rapamycin Inhibitor Everolimus on Hepatitis C Virus Replication In Vitro and In Vivo.

Background: The influence of immunosuppressants on hepatitis C virus (HCV) re-infection after liver transplantation, particularly mammalian target of rapamycin inhibitors, remains unclear. The aim of our study was to analyze the influence of everolimus (EVR) on HCV replication activity in the context of underlying molecular mechanisms, with focus on the pro-myelocytic leukemia protein (PML).

Methods: HCV viral load was recorded in 40 patients with post-transplant HCV re-infection before and 8 weeks after introduction of EVR.

Experimental study of the magnetic field enhanced Payne effect in magnetorheological elastomers.

The dynamic modulus and the loss factor of magnetorheological elastomers (MREs) of various compositions and anisotropies are studied by dynamic torsion oscillations performed in the absence and in the presence of an external magnetic field. The emphasis is on the Payne effect, i.e.

Cement augmentation in spinal tumors: a systematic review comparing vertebroplasty and kyphoplasty.

Study Design:  Comparative effectiveness review.

Study Rationale:  The spine is among the most common location for bony metastases. In many cases these metastases cause fractures leading to increased morbidity.

Fusion versus nonoperative management for chronic low back pain: do sociodemographic factors affect outcome?

Study Design: Systematic review.

Objective: The objectives of this systematic review were to determine whether sociologic and demographic factors modify the effect of fusion versus nonoperative management in patients with chronic low back pain.

Summary Of Background Data: Chronic low back pain is among the most common symptoms leading patients to seek medical care and presents significant challenges in treatment decision making.

Pharmacologic management of chronic low back pain: synthesis of the evidence.

Study Design: Systematic review of the literature with subgroup analysis for heterogeneous treatment effects.

Objective: The objectives of this systematic review were to summarize prior Cochrane reports regarding the safety and effectiveness of opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and antidepressants for treatment of chronic low back pain (LBP) and to evaluate whether certain subpopulations respond more favorably to pharmacological management.

Summary Of Background Data: While medications are a mainstay of LBP management, there is uncertainty as to the optimal use of commonly prescribed medications such as opioids, antidepressants, and NSAIDS.