Publications by authors named "E E Testai"
Organophosphorothioates (OPT) are pesticides impacting human, animal and environmental health. They enter the environment worldwide, primarily due to their application as insecticides. OPTs are mainly neurotoxic upon bioactivation and inhibition of brain and serum acetylcholinesterase (AChE).
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- Bisphenol A (BPA) is a synthetic chemical linked to harmful health effects like metabolic and reproductive issues, leading to its classification as toxic in the EU and resulting in bans or restrictions on its use.
- Industries have started using alternatives like bisphenol S (BPS) and bisphenol F (BPF), which are also toxic and currently being regulated, while other less-known BPA substitutes are emerging.
- This review highlights the hazards of various BPA alternatives, focusing on their toxicological data related to endocrine disruption, immunotoxicity, and other health risks, with goals to identify knowledge gaps and improve chemical risk assessment methods under the European Partnership for the Assessment of Risks from Chemicals (PARC) project.
The focus on implementation of systematic review (SR) principles in chemical risk assessments (CRAs) is growing as it has the potential to advance the rigour and transparency of the CRAs. However, the SR and CRA communities use their own specific terminologies. Understanding the meaning of core SR and CRA terms and where they overlap is critical for application of SR methods and principles in CRAs.
View Article and Find Full Text PDFIntroduction: Communities affected by large scale and long lasting industrial contamination are often keen to understand whether their health has been impaired by such contamination. This requires answers that integrate environmental public health and environmental justice perspectives. At these sites, exposure scenarios from environmental contamination over time by multiple chemicals, often involving different environmental matrices, are complex and challenging to reconstruct.
View Article and Find Full Text PDFThis protocol describes the design and development of a tool for evaluation of the internal validity of studies, which is needed to include the data as evidence in systematic reviews and chemical risk assessments. The tool will be designed specifically to be applied to cell culture studies, including, but not restricted to, studies meeting the new approach methodology (NAM) definition. The tool is called INVITES-IN (IN VITro Experimental Studies INternal validity).
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