Publications by authors named "E E Sitarz"
Article Synopsis
- There is growing evidence that infections, typically known for causing gastrointestinal issues, may also contribute to a variety of extragastric diseases affecting different systems in the body, including neurological disorders.
- This review specifically examines the connection between infection and neurological disorders, emphasizing the impact on the gut-brain axis and changes in gut microbiota due to infections.
- Most current research on the link between infection and neurological impairments primarily concentrates on a specific type of infection, though this area is still developing.
The identification of biomarkers as diagnostic tools and predictors of response to treatment of neurological developmental disorders (NDD) such as schizophrenia (SZ), attention deficit hyperactivity disorder (ADHD), or autism spectrum disorder (ASD), still remains an important challenge for clinical medicine. Metallomic profiles of ASD patients cover, besides essential elements such as cobalt, chromium, copper, iron, manganese, molybdenum, zinc, selenium, also toxic metals burden of: aluminum, arsenic, mercury, lead, beryllium, nickel, cadmium. Performed studies indicate that children with ASD present a reduced ability of eliminating toxic metals, which leads to these metals' accumulation and aggravation of autistic symptoms.
View Article and Find Full Text PDFEpithelial-mesenchymal transition (EMT) constitutes one of the hallmarks of carcinogenesis consisting in the re-differentiation of the epithelial cells into mesenchymal ones changing the cellular phenotype into a malignant one. EMT has been shown to play a role in the malignant transformation and while occurring in the tumor microenvironment, it significantly affects the aggressiveness of gastric cancer, among others. Importantly, after EMT occurs, gastric cancer patients are more susceptible to the induction of resistance to various therapeutic agents, worsening the clinical outcome of patients.
View Article and Find Full Text PDFElastin is a major polymeric protein of the extracellular matrix, providing critical properties of extensibility and elastic recoil. The rs2071307 genomic polymorphism, resulting in the substitution of a serine for a glycine residue in a VPG motif in tropoelastin, has an unusually high minor allele frequency in humans. A consequence of such allelic heterozygosity would be the presence of a heterogeneous elastin polymer in up to 50% of the population, a situation which appears to be unique to Homo sapiens.
View Article and Find Full Text PDFArticle Synopsis
- Changes in serum trace element levels are frequently observed in patients with psychiatric disorders, potentially serving as diagnostic and prognostic biomarkers.
- The study conducted a systematic review of 59 eligible articles selected from over 5,000 sources to assess trace element alterations specifically in schizophrenia.
- While the study found no consistent serum trace element levels in schizophrenic patients to support their use as reliable markers, altered concentrations may still be significant in regard to symptoms and cognitive impairments.