Publications by authors named "E E Sharpe"

Article Synopsis
  • The study investigates the relationship between the obstetric co-morbidity index (OBCMI) and severe maternal morbidity (SMM) in women transferred for antepartum care to a high-level maternal facility from 2016 to 2020.
  • Findings show that women transferred for maternal reasons had a higher median OBCMI and a significantly greater prevalence of SMM compared to those transferred for fetal conditions, indicating a disparity in risks based on the reason for transfer.
  • An OBCMI score of ≥4 was identified as a predictive marker for SMM, showing high sensitivity and was associated with increased complications such as operative delivery and prolonged hospital stays.
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Background: A personal statement is a common requirement in medical residency and fellowship applications. Generative artificial intelligence may be used to create a personal statement for these applications.

Methods: Two personal statements were created using OpenAI's Chat Generative Pre-trained Transformer (ChatGPT) and two applicant-written statements were collected.

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Background: Sugammadex, aprepitant, and fosaprepitant are increasingly used perioperatively. These medications may interfere with the effectiveness of hormonal contraception. This study assessed anesthesia providers' use of sugammadex and aprepitant, their knowledge of interactions with hormonal birth control, and patient counseling practices to identify possible knowledge gaps or opportunities for practice improvement.

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Purpose Of Review: Medication administration errors represent a significant yet preventable cause of patient harm in the peripartum period. Implementation of best practices contained in this manuscript can significantly reduce medication errors and associated patient harm.

Recent Findings: Cases of medication errors involving unintended intrathecal administration of tranexamic acid highlight the need to improve medication safety in peripartum patients and obstetric anesthesia.

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Autosomal-dominant polycystic kidney disease (ADPKD) is a common monogenic disease characterized by the formation of fluid-filled renal cysts, loss of mitochondrial function, decreased fatty acid oxidation, increased glycolysis, and likely renal failure. We previously demonstrated that inducing a state of ketosis ameliorates or reverses PKD progression in multiple animal models. In this study, we compare time-restricted feeding and 48-h periodic fasting regimens in both juvenile and adult Cy/+ rats.

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