Visualization for better understanding global sensitivity analysis results: The case of safety assessment of radioactive waste disposal.

Sensitivity analysis answers questions about the influence of parameters on the simulation results and plays a significant role in the development of environmental models by helping to understand the relations within the model and test its adequacy. Comparison of various sensitivity analysis approaches is often also quite useful because different methods employ different measures for ranking model parameters and their unconformities and disagreements provide additional information on model behavior. The visual representation of numerical results is crucial for their correct interpretation, and at first sight, the visualizations for the sensitivity analysis should be quite universal because in most cases an outcome of sensitivity analysis is the same: a set of indices measuring the significance of model inputs for the selected output.

Phyto-nano-hybrids of Ag-CuO particles for antibacterial activity against drug-resistant pathogens.

Background: The present study reports the antibacterial potential of phyto-nano-hybrid particles Ag-CuO (silver-copper oxide) against drug-resistant pathogens isolated from a Russian hospital in Krasnoyarsk, Siberia. The synthesis of nano-hybrid was achieved by phytogenic source by using leaves of Murraya koenigii. The nano-hybrid particles were well characterized using hyphenated techniques and results of the antibacterial assay was tabulated.

[The inhibitors of the apical sodium-dependent bile acid transporter (ASBT) as promising drugs].

Inhibition of the apical sodium-dependent bile acid transporter (ASBT, also known as IBAT - ileal bile acid transporter, SLC10A2) leads to disruption of the enterohepatic circulation of bile acids and their excretion with fecal masses. This is accompanied by cholesterol utilization for synthesis of new bile acids. ASBT inhibitors are promising drugs for the treatment of such diseases as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, type 2 diabetes mellitus, necrotic enterocolitis, chronic constipation, atherosclerosis.

[Vascular mechanisms in Meniere's disease].

Meniere's disease (MD) is chronic multifactorial medical condition caused by endolymphatic hydrops, which etiology is unclear. This review highlights possible vascular mechanisms of MD. Impairment of vascular regulation, further ischemic damage of labyrinth and venous drainage pathology could lead to endolymphatic hydrops.

[Improvement of laboratory diagnostics of cholera due to genetically altered (hybrid) variants of cholera Vibrio biovar El Tor].

Aim: Improvement of laboratory diagnostics of cholera taking into the account appearance of hybrid variants of cholera vibrio El Tor biovar in the 1990s.

Materials And Methods: Phenotypic and molecular-genetic properties of typical toxigenic (151 strains) and hybrid (102 strains) variants of El Tor biovar cholera vibrios, isolated in the Caucuses in 1970-1990 and 1993-1998, respectively, were studied. Toxigenicity gene DNA fragments, inherent to El Tor biovars or classic, were detected by using a reagent kit "Genes of Vibrio cholerae variant ctxB-rstR-rstC, REF" developed by us.