Publications by authors named "E E NISKANEN"
Article Synopsis
- The inflammatory tumor microenvironment (TME) significantly contributes to cancer progression, particularly in prostate cancer.
- Tumor-associated macrophages (especially M1, pro-inflammatory types) promote cancer stemness while suppressing androgen response in prostate cancer cells.
- The study suggests that M1 macrophages do this by releasing factors that activate the NFκB signaling pathway, leading to increased expression of cancer stem cell markers like NANOG and KLF4.
The androgen receptor (AR) is pivotal in prostate cancer (PCa) progression and represents a critical therapeutic target. AR-mediated gene regulation involves intricate interactions with nuclear proteins, with many mediating and undergoing post-translational modifications that present alternative therapeutic avenues. Through chromatin proteomics in PCa cells, we identified SUMO ligases together with nuclear receptor coregulators and pioneer transcription factors within the AR's protein network.
View Article and Find Full Text PDFMost common genetic variants associated with disease are located in non-coding regions of the genome. One mechanism by which they function is through altering transcription factor (TF) binding. In this study, we explore how genetic variation is connected to differences in the regulatory landscape of livers from C57BL/6J and 129S1/SvImJ mice fed either chow or a high-fat diet.
View Article and Find Full Text PDFTreatment of prostate cancer relies predominantly on the inhibition of androgen receptor (AR) signaling. Despite the initial effectiveness of the antiandrogen therapies, the cancer often develops resistance to the AR blockade. One mechanism of the resistance is glucocorticoid receptor (GR)-mediated replacement of AR function.
View Article and Find Full Text PDFBackground: Accumulating evidence indicates importance of RNA regulation in cancer. This includes events such as splicing, translation, and regulation of noncoding RNAs, functions which are governed by RNA binding proteins (RBPs).
Aims: To find which RBPs could be relevant for prostate cancer, we performed systematic screening of RBP expression in clinical prostate cancer.